OBJECTIVE To investigate the antifungal activity of plagiochin E against the strains of Candida albicans in vitro,and the interactions of fluconazole with plagiochin E against the sensitive and resistant strains.METHODS A broth micro-dilution method was used to determine the MICs of plagiochin E for the fifteen sensitive and four resistant strains.The combination effect of plagiochin E and fluconazole was also assessed.RESULTS The MIC of plagiochin E was 16 mg·L-1 against the fifteen sensitive strains.Plagiochin E had the same MIC against resistant strains.After the administration of plagiochin E and fluconazole at the same time,MICs of two drugs were lower against both resistant strains and sensitive ones.Additive effect on sensitive strains and synergic effect on resistant strains were observed respectively.CONCLUSION Plagiochin E has a moderate but significant antifungal action on the sensitive and resistant strains of C.albicans,and shows additive or synergy effect after the administration of fluconazole.Plagiochin E can be useful for antifungal therapy and has a potential action on reversing the resistance of C.albicans against fluconazole.
LENG Ping;GUO Xiu-li;YNG Yue;LOU Hong-xing.
Primary Study on Antifungal Activities and Reversal of Fluconazole Resistance of Plagiochin E [J]. Chinese Pharmaceutical Journal, 2007, 42(05): 349-352
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