摘要
目的研究阿魏酸钠微孔渗透泵片在Beagle犬体内的药动学。方法以阿魏酸钠普通片为对照,应用HPLC测定血药浓度。结果阿魏酸钠微孔渗透泵片和普通片的tmax分别为(4.833±0.725)和(1.000±0)h,t1/2分别为(12.892±2.879)和(5.824±1.659)h,ρmax分别为(2.227±0.583)和(12.942±1.568)mg·L-1。相对生物利用度为98.4%。结论阿魏酸钠微孔渗透泵片血药浓度平稳,可较长时间保持血药浓度。
Abstract
OBJECTIVE To study the pharmacokinetics and bioavailability of Sodium Ferulate porosity osmotic pump tablets in beagle dogs.METHODS With sodium ferulate conventional tablets as reference,sodium ferulate concent-ration was determined by HPLC.RESULTS Main pharmacokinetic parameters were as follows: tmax(4.833±0.725) and(1.000±0)h,t1/2(12.892±2.879)and(5.824±1.659)h,ρmax(2.227±0.583) and(12.942±1.568)mg·L-1,for sodium ferulate porosity osmotic pump tablets and reference tablets,respectively.Relative bioavailability was 98.4%.CONCLUSION Plasma concentrations of sodium ferulate porosity osmotic pump tablets are constant and effective plasma drug concent-ration is kept for a long time.
关键词
阿魏酸钠 /
微孔渗透泵片 /
高效液相色谱法 /
生物利用度 /
药动学
{{custom_keyword}} /
Key words
sodium ferulate /
porosity osmotic pump tablets /
HPLC /
bioavailability /
pharmacokinetics
{{custom_keyword}} /
何黎黎;张志荣;李立立;郑玲利.
阿魏酸钠微孔渗透泵片的体内药动学与生物利用度[J]. 中国药学杂志, 2007, 42(04): 295-297
HE Li-li;ZHNG Zhi-rong;LI Li-li;ZHENG Ling-li.
Pharmacokinetics and Bioavailability of Sodium Ferulate Porosity Osmotic Pump Tablets in Beagle Dogs [J]. Chinese Pharmaceutical Journal, 2007, 42(04): 295-297
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] GAYLEN M，ZENTNER，GERALD S，et al.Osmotic flow through controlled poroslty films： an approach to delivery of water soluble compounds [J] .J Controlled Release，1985，2：217-229.
[2] SANTUS G，BAKER R W.Osmotic drug delivery： A review of the patent literature [J] .J Controlled Release，1995，35： 1-21.
[3] LI X，LI C，WANG H Z，et al.Study on the pharmacokinetics parameters of Sodium Ferulate in vivo[J] .J Chin Med Pharmacol(中医药学报)，1992，4：53.
[4] LIU W J，YANG L，QIN W J. Determination of ferulic acid in rat serum by HPLC after oral administration of shu guan liquid extract[J] .Chin Pharm J(中国药学杂志)，2001，36(5)：339-340.
[5] XIA D Y，GUO T，PAN W H，et al. Determination of plasma level of ferulic acid in Xinshu Oral Liquid by HPLC and its in vivo pharmacokinetics in rats[J] .Chin Tradit Herb Drugs(中草药)，2004，35(1)：36-38.
[6] XU S，HU J H，LI F Q. Determination of sodium ferulate in Beagle dog plasma by HPLC and its pharmacokinetics[J] .Chin Tradit Patent Med(中成药)，2005，27（9）：1062-1065.
[7] DING M Y，MA S W，LIU D L. Stability of ferulic acid and its existing form in Ligusticum chuanxiong and Angelica sinensis[J] . Chin Tradit Herba Drugs(中草药)，2004，35(1)： 28-30.
[8] ZHAO Y，JIANG X H，ZHOU T J，et al. Pharmacokinetics of sodium fluoride sustained-release tablet and the correlation between the absorption in vivo and the releasing rate in vitro[J] .Mod Med Health(现代医药卫生)，2004，20(12)： 1086-1087.
[9] LIA X，PANA W，NIE S，et al.Studies on controlled release effervescent osmotic pump tablets from traditional chinese medicine compound recipe[J] .J Controlled Release，2004，96： 359-367.
[10] ZHANG Y，ZHANG Z R，WU F.A novel pulsed-release system based on swelling and osmotic pumping mechanism[J] .J Controlled Release，2003，89： 47-55.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
