基于生物组学(-omics)的免疫功能基因的发现

吴龙妍;张建;田志刚

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (21) : 1609-1612.

中国药学杂志 ›› 2006, Vol. 41 ›› Issue (21) : 1609-1612.
综述

基于生物组学(-omics)的免疫功能基因的发现

  • 吴龙妍;张建;田志刚
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摘要

目的从基因组学、蛋白质组学和转录组学角度,对目前基于生物组学(-omics)发现免疫学新功能基因的方法进行综述。方法参阅近年来国内外有关综述进行总结,并对现有常用方法进行比较和评价。结果现有一些成型的实验方法用于免疫功能基因的发现,经典的实验方法不断得到改进,新的实验手段也取得显著的成果。结论生物信息学方法占主流地位,但以实验为基础的差减杂交和杂交核酶技术也显示出其优势。

关键词

功能基因 / 基因组学 / 蛋白质组学 / 转录组学 / 免疫功能

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吴龙妍;张建;田志刚. 基于生物组学(-omics)的免疫功能基因的发现[J]. 中国药学杂志, 2006, 41(21): 1609-1612

参考文献

[1] ROGIC S,MACKWORTH A K,OUELLETTE F B . Evaluation of gene-finding programs on mammalian sequences[J] .Genome Res,2001,11(5):817-832. [2] WANG C L,ZHANG S C,WANG C F. Localization of genes on chromosome[J] . Bull Biol (生物学通报),1999,8 (8):18-20. [3] HORRIGAN S K,BARTOLONI L,SPEER M C. A radiation hybrid breakpoint map of the acute myeloid leukemia (AML) and limb-girdle muscular dystrophy 1A (LGMD1A) regions of chromosome 5q31 localizing 122 expressed sequences[J] .Genomics,1999,57(1):24-35. [4] BOGUSKI M S,TOLSTOSHEV C M,BASSETT D E,et al. Gene discovery in dbEST[J] . Science,1994,265(5181):1993-1994. [5] LIU Z,WOMACK J E,ANTONIOU E. A high-resolution comparative RH map of the telomeric end of bovine chromosome 2 with human chromosomes 1 and 2[J] . Cytogenet Genome Res,2003,103(1-2):89-93. [6] CHOWDHARY B P,RAUDSEPP T,KATA S R,et al. The first-generation whole-genome radiation hybrid map in the horse identifies conserved segments in human and mouse genomes[J] .Genome Res,2003,13(4):742-751. [7] LEE E J,RAUDSEPP T,KATA S R,et al. A 1.4-Mb interval RH map of horse chromosome 17 provides detailed comparison with human and mouse homologues[J] .Genomics,2004,83(2):203-215. [8] EVERTS-VAN DER WIND A,KATA S R,BAND M R,et al. A 1463 gene cattle-human comparative map with anchor points defined by human genome sequence coordinates[J] .Genome Res,2004,14(7):1424-1437. [9] SHI S Y,DING D F. A evolutionary approach to identification of orthologous relationship across proteomes[J] .Acta Biochim Biophys Sin(生物化学与生物物理学报),2002,34(1):88-94. [10] ROSEN C A,KENNY J J. Polynucleotides encoding interleukin-19:United States,5,985,614[P] . 1999-11-16. [11] SHI Y,ULLRICH S J,ZHANG J,et al. A novel cytokine receptor-ligand pair. Identification,molecular characterization,and in vivo immunomodulatory activity[J] .J Biol Chem,2000,275(25):19167-19176. [12] PARRISH-NOVAK J,DILLON S R,NELSON A,et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function[J ] . Nature,2000,408(6808):57-63. [13] XIE M H,AGGARWAL S,HO W H,et al. Interleukin(IL)-22,a novel human cytokine that signals through the interferon receptor-related proteins CTF2-4 and IL-22R[J] .J Biol Chem,2000,275(40):31335-31339. [14] OPPMANN B,LESLEY R,BLOM B,et al. Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12[J] .Immunity,2000,13(5):715-725. [15] CONTI P,KEMPURAJ D,FRYDAS S,et al. IL-10 subfamily members: IL-19,IL-20,IL-22,IL-24 and IL-26[J] .Immunol Lett,2003,88(3):171-174. [16] GALPERIN M Y,KOONIN E V. Who′s your neighbor?New computational approaches for functional genomics[J] . Nat Biotechnol,2000,18(6):609-613. [17] SCHEETZ T,BARTLETTJ A,WALTERS J D,et al. Genomics-based approaches to gene discovery in innate immunity[J] . Immunol Rev,2002,190:137-145. [18] SUN C,KILBURN D,LUKASHIN A,et al. Kirrel2,a novel immunoglobulin superfamily gene expressed primarily in beta cells of the pancreatic islets[J] . Genomics,2003,82 (2):130-142. [19] KASOF G M,GOMES B C. Livin,a novel inhibitor of apoptosis protein family member[J] . J Biol Chem,2001,276(5):3238-3246. [20] PATTON W F. Detection technologies in proteome analysis[J] .J Chromatogr B Analyt Technol Biomed Life Sci,2002,771(1-2):3-31. [21] ZHANG H Y. Progress on the techniques of proteomics[J] . Biotechnol Bull(生物技术通报),2005,21(4):31-36. [22] ZHOU G,LI H,DECAMP D,et al. 2D differential in-gel electrophoresis for the identification of esophageal scans cell cancer-specific protein markers[J] . Mol Cell Proteomics,2002,1(2):117-124. [23] LAI C H,CHOU C Y,CHANG L Y,et al. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics[J] . Genome Res,2000,10(5):703-713. [24] CUFF J A,BIRNEY E,CLAMP M E,et al. ProtEST: protein multiple sequence alignments from expressed sequence tags[J] . Bioinformatics,2000,16(2):111-116. [25] HAN W L,LI Y,ZHANG Y M,et al. Isolation of genes that are inhibited by IL-10 in U937 cells by suppression subtractive hybridization(SSH)[J] . Chin J Microbiol Immunl(中华微生物学和免疫学杂志),2000,20(2):128-131. [26] MA D L. Discovery and functional clarification of novel human genes encoding cytokines and apoptosis-related molecules[J] . J Peking Univ(Health Sciences)[北京大学学报(医学版)] ,2002,34(5):488-492. [27] KNAPPE A,HOR S,WITTMANN S,et al. Induction of a novel cellular homolog of interleukin-10,AK155,by transformation of T lymphocytes with herpesvirus saimiri[J] . J Virol,2000,74(8):3881-3887. [28] JIANG H,LIN J J,SU Z Z,et al. Subtraction hybridization identifies a novel melanoma differentiation associated gene,mda-7,modulated during human melanoma differentiation,growth and progression[J] .Oncogene,1995,11(12):2477-2486. [29] KIM Y S,LEWANDOSKI M,PERANTONI A O. Identification of Glis1,a novel Gli-related,Kruppel-like zinc finger protein containing transactivation and repressor functions[J] . J Biol Chem,2002,277(34):30901-3091313. [30] KATO Y,TSUNEMI M,MIYAGISHI M,et al. Functional gene discovery using hybrid ribozyme libraries[J] . Methods Mol Biol,2004,252:245-256. [31] KAWASAKI H,TAIRA K. A functional gene discovery in the Fas-mediated pathway to apoptosis by analysis of transiently expressed randomized hybrid-ribozyme libraries[J] . Nucleic Acids Res,2002,30(16):3609-3614. [32] SUYAMA E,KAWASAKI H,NAKAJIMA M,et al. Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes[J] . Proc Natl Acad Sci USA,2003,100(10):5616-5621. [33] WADHWA R,YAGUCHI T,KAUR K,et al. Use of a randomized hybrid ribozyme library for identification of genes involved in muscle differentiation[J] . J Biol Chem,2004,279(49):51622-516299. [34] KAWASAKI H,TSUNEMI M,IYO M,et al. A functional gene discovery in cell differentiation by hybrid ribozyme and siRNA libraries[J] . Nucleic Acids Res Suppl,2002,(2):275-276. [35] BUBENDORF L. High-throughput microarray technologies: from genomics to clinics[J] .Eur Urol,2001,40(2):231-238. [36] MAECKER B,VON BERGWELT-BAILDON,ANDERSON K S,et al. Linking genomics to immunotherapy by reverse immunology immunomics′ in the new millennium[J] . Curr Mol Med,2001,1(5):609-619. [37] OU Y,WANG S,CAI Z,et al. ZNF328,a novel human zinc-finger protein,suppresses transcriptional activities of SRE and AP-1[J] . Biochem Biophys Res Commun,2005,333(3):1034-1044. [38] GOU D,WANG J,GAO L,et al. Identification and functional analysis of a novel human KRAB/C2H2 zinc finger gene ZNF300[J] . Biochim Biophys Acta,2004,1676(2):203-209.

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