摘要
目的介绍分子印迹技术及分子印迹聚合物,综述分子印迹聚合物在各类给药系统中的应用。方法对近几年发表的相关论文进行全面地回顾和整理,阐述分子印迹聚合物在药物传递系统中的研究进展。结果随着分子印迹技术的进步,分子印迹聚合物已被用于设计多种新型药物传递系统,包括缓控释给药系统、药物载体、刺激敏感型给药系统、靶向给药系统以及捕获系统。结论尽管分子印迹聚合物在给药系统中的应用尚处于起步阶段,但用分子印迹聚合物设计的药物传递系统以其独特的优势正受到人们越来越多的关注,利用分子印迹聚合物将能制备出更独特、更智能的药物传递系统。
关键词
分子印迹聚合物 /
缓控释给药系统 /
刺激敏感型给药系统 /
靶向给药系统 /
捕获系统
{{custom_keyword}} /
张勇;周建平.
分子印迹给药系统研究进展[J]. 中国药学杂志, 2006, 41(21): 1605-1608
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1]LANGER R,PEPPAS N A. Advances in biomaterials,drug delivery,and bionanotechnology[J].AIChE Journal,2003,49(12):2990-3006.
[2]MARTIN-ESTEBAN A. Molecular imprinting technology: a simple way of synthesizing biomimetic polymeric receptors[J].Anal Bioanal Chem,2004,378(8):1875.
[3]PILETSKY S A,ALCOCK S,TURNER A P. Molecular imprinting:at the edge of the third millennium[J].Trends Biotechnol,2001,19(1):9-12.
[4]ALVAREZ-LORENZO C,CONCHEIRO A. Molecularly imprinted polymers for drug delivery[J].J Chromatogr B Analyt Technol Biomed Life Sci,2004,804(1):231-245.
[5]PUOCI F,IEMMA F,MUZZALUPO R,et al. Spherical molecularly imprinted polymers (SMIPs) via a novel precipitation polymerization in the controlled delivery of sulfasalazine[J].Macromol Biosci,2004,4(1):22-26.
[6]CAI W,GUPTA R B. Molecularly-imprinted polymers selective for tetracycline binding[J].Sep Purif Technol,2004,35:215-221.
[7]SUEDEE R,SRICHANA T,RATTANANONT T. Enantioselective release of controlled delivery granules based on molecularly imprinted polymers[J].Drug Deliv,2002,9(1):19-30.
[8]ALVAREZ-LORENZO C,HIRATANI H,GOMEZ-AMOZA J L,et al. Soft contact lenses capable of sustained delivery of timolol[J].J Pharm Sci,2002,91(10):2182-2192.
[9]HIRATANI H,ALVAREZ-LORENZO C. The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems[J].Biomaterials,2004,25(6):1105-1113.
[10]RACHKOV A,MINOURA N. Towards molecularly imprinted polymers selective to peptides and proteins.The epitope approach[J].Biochim Biophys Acta,2001,1544(1-2):255-266.
[11]DAVIS M E,BREWSTER M E. Cyclodextrin-based pharmaceutics: past,present and future[J].Nat Rev Drug Discov,2004,3(12):1023-1035.
[12]ASANUMA H,AKIYAMA T,KAJIYA K,et al. Molecular imprinting of cyclodextrin in water for the recognition of nanometer-scaled guests[J].Anal Chim Acta,2001,435(1):25-33.
[13]TSAI H A,SYU M J. Synthesis of creatinine-imprinted poly(beta-cyclodextrin) for the specific binding of creatinine[J].Biomaterials,2005,26(15):2759-2766.
[14]MORITANI T,ALVAREZ-LORENZO C. Conformational imprinting effect on stimuli-sensitive gels made with an imprinter monomer[J].Macromolecules,2001,34:7796-7803.
[15]KARMALKAR R N,KULKARNI M G,MASHELKAR R A. Pendent chain linked delivery systems: II. Facile hydrolysis through molecular imprinting effects[J].J Control Release,1997,43(2-3):235-243.
[16]SREENIVASAN K. On the application of molecularly imprinted poly(HEMA) as a template responsive release system[J].J Appl Polym Sci,1999,71:1819-1821.
[17]MATSUMOTO A,YOSHIDA R,KATAOKA K. Glucose-responsive polymer gel bearing phenylborate derivative as a glucose-sensing moiety operating at the physiological pH[J].Biomacromolecules,2004,5(3):1038-1045.
[18]BYRNE M E,PARK K,PEPPAS N A. Molecular imprinting within hydrogels[J] .Adv Drug Deliv Rev,2002,54(1):149-161.
[19]WIZEMAN W J,KOFINAS P. Molecularly imprinted polymer hydrogels displaying isomerically resolved glucose binding[J] .Biomaterials,2001,22(12):1485-1491.
[20]GORE M A,KARMALKAR R N,KULKARNI M G. Enhanced capacities and selectivities for cholesterol in aqueous media by molecular imprinting: role of novel cross-linkers[J] .J Chromatogr B Analyt Technol Biomed Life Sci,2004,804(1):211-221.
[21]CRISTALLINI C,CIARDELLI G,BARBANI N,et al. Acrylonitrile-acrylic acid copolymer membrane imprinted with uric acid for clinical uses[J] .Macromol Biosci,2004,4(1):31-38.
[22]KUBO T,HOSOYA K,WATABE Y,et al. Toxicity recognition of hepatotoxin,homologues of microcystin with artificial trapping devices[J] .J Environ Sci Health A Tox Hazard Subst Environ Eng,2004,39(10):2597-2614.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}