Population Pharmacodynamics of Propofol in Neurosurgical Patients
LI Yu-hong1,XU Jian-hong1,RUI Jian-zhong2,XU Jian-guo3
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1. Department of Anesthesiology,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou 310003,China; 2. Department of Clinical Pharmacology,Nanjing 210002,China; 3. Department of Anesthesiology,Jinling Hospital,Nanjing 210002,China
OBJECTIVE To analyze population pharmacodynamics of propofol in neurosurgical patients and to discuss the influences of the age, weight or gender on the propofol pharmacodynamics. METHODS Twenty-seven ASA Ⅰ~Ⅱ elective neurosurgical patients were treated with propofol 2 mg·kg-1 for 5 min and maintained the infusion of propofol 10 mg·kg-1·h-1 for 5 min. CSF and arterial blood were collected simultaneously before infusion and at different time points after infusion. The concentrations of propofol were measured with HPLC with fluorescence detection. At the same time of sample collection,BIS index(BIS)was recorded. Model simulation was performed and the influences of age, weight, and gender were investigated by using NONMEM program.RESULTS The parameters of a and b for linear addictive model were 1.11 and 95.4; the parameters of a and b for linear exponential model were 1.05 and 92.7; the parameters of Emax, EC50 and N for Sigmoid Emax model were 119,53.6 and 1.51, respectively. The predicted concentrations of CSF showed a good correlation with the measured concentrations(r2 were 0.911 2, 0.9146, and 0.926, respectively). CONCLUSION Linear additive, linear exponential and Sigmoid Emax models can describe the pharmacodynamics of propofol.
LI Yu-hong;XU Jin-hong;RUI Jin-zhong;XU Jin-guo.
Population Pharmacodynamics of Propofol in Neurosurgical Patients [J]. Chinese Pharmaceutical Journal, 2006, 41(17): 1334-1337
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