1.Research Institute of Cardiovascalar Disease，First Affiliated Hospital Nanjing Medical University，Nanjing 210029，China； 2.Shanghai Nutrient Research Institute of Life Science，Chinese Academy of Science，Shanghai 200031，China
OBJECTIVE To investigate the effect and mechanism of astragalosides on myocardial injury induced by isoproterenol in rats.METHODS All rats were divided into five groups: normal,isoproterenol,astragalosides, trimetazidine and propranolol group.Rats injuried by isoproterenol(5 mg·kg-1·d-1 7d,sc)were treated with astragalosides(5 mg·kg-1·d-1 7d,ip), trimetazidine(10 mg·kg-1·d-1-1·d-1 7d,ip)respectively. Pathological changes, lactic acid(LA)and malondialdehyde(MDA)in myocardium were detected. The primary high energy phosphates such as ATP, ADP and AMP in myocardium were determined by high performance liquid chromatography.RESULTS Isoproterenol induced myocardial necrosis. After being treated with astragalosides, the pathological section of myocardium almost approached to that of trimetazidine group.Compared with isoproterenol group, the levels of LA and MDA in myocardium of astragalosides group decreased significantly(P<0.05, P<0.01,respectively), ATP level increased(P<0.05),ADP level decreased(P<0.05),AMP level tended to increase. No significant difference was obtained between the groups treated with astragalosides and trimetazidine (P>0.05).CONCLUSION Astragalosides may prevent the myocardial injury induced by isoproterenol. One of mechanisms is to improve energy metabolism and prevent the lipid peroxidation.
FENG Lin;MENG Dn;CHEN Xing-jin;YNG Di;ZHNG Ji-nn.
Protective Action of Astragalosides on Myocardial Injury Induced by Isoproterenol in Rats [J]. Chinese Pharmaceutical Journal, 2006, 41(17): 1313-1315
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