摘要
目的研究中药牛膝中蜕皮甾酮类成分。方法采用大孔树脂、硅胶、ODS柱色谱分离纯化,经理化常数、光谱学方法鉴定结构。结果分离得到了3种蜕皮甾酮类成分,其结构分别为:2β,3β,5β,14α,20β,22α,25-七羟基-7-烯-胆甾-6-酮(polypo-dineB,1);2β,3β,14α,20β,22α,25-六羟基-7-烯-胆甾-6-酮(β-蜕皮甾酮,2);2β,3β,20β,22α,25-五羟基-8,14-二烯-胆甾-6-酮(3)。结论化合物3是新化合物。
Abstract
OBJECTIVE To investigate the steroid constituents of Achyranthes bientata Bl.. METHODS Solvent extraction and column chromatography were used to isolate the non-alkaloid constituent, and physico-chemical constants and spectroscopic analysis were employed for structural elucidation.RESULTS Three steroid constituents were isolated and their structures were elucidated to be 2β,3β,5β,14α,20β,22α,25-heptahydroxy-cholest-7-en-6-one (Polypodine B,1);2β,3β,14α,20β,22α,25-hexahydroxy-cholest-7-en-6-one(2);2β,3β,20β,22α,25-pentahydroxy-cholesta-8,14-dien-6-one(3),respectively. CONCLUSION Compound 3 is a new compound.
关键词
牛膝 /
甾醇
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Key words
Achyranthes bientata /
steroids
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林大专;王广树;杨晓虹;徐景达.
牛膝中新蜕皮甾酮类成分的研究[J]. 中国药学杂志, 2006, 41(17): 1295-1297
LIN D-zhun;WNG Gung-shu;YNG Xio-hong;XU Jing-d.
Studies on Steroid Constituents of Achyranthes bientata Bl. [J]. Chinese Pharmaceutical Journal, 2006, 41(17): 1295-1297
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参考文献
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脚注
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