目的介绍近年来黄酮类化合物在Caco-2细胞模型上的转运和代谢研究进展。方法总结了国内外有关黄酮类化合物在Caco-2细胞模型上的生物利用度研究、黏膜毒性、药物相互作用和吸收转运机制;体外代谢中的结构-代谢关系、对代谢酶的影响以及动态代谢模型和酶-转运体合用模型的应用等。结果和结论对黄酮类化合物在Caco-2细胞模型上的转运和代谢的研究,可以用来研究该类化合物的吸收机制、预测其体内吸收和药物相互作用。
关键词
黄酮类化合物 /
Caco-2细胞模型 /
体外转运和代谢
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参考文献
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脚注
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基金
浙江省中医药管理局资助项目(No·G20010358);浙江省科技厅重点资助项目(No·G20020578)
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