摘要
目的对目前抗人类免疫缺陷病毒(HIV)药物进行分类,并综述了抗HIV药物新剂型的研究进展。方法对近年国内外相关文献进行分析和归纳。结果抗HIV药物的不良反应和耐受性问题可通过选用合适的剂型如脂质体、透皮给药等得以改善。结论为进一步提高抗HIV药物的疗效,减缓机体对这类药物的耐受性,应深入研究一些能将该类药物有效传递到HIV病毒贮库的新剂型。
关键词
人类免疫缺陷病毒 /
药物 /
新剂型 /
研究进展
{{custom_keyword}} /
张玲玲;邓意辉;雷杰杰;吴红兵;陶昱斐;沈琳;石莉.
抗人类免疫缺陷病毒药物及其新剂型的研究进展[J]. 中国药学杂志, 2006, 41(17): 1285-1289
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] GAO Y,LUO D D. Progress in anti-HIV nucleoside analogues[J]. Foreign Med Sci(Epidemiol Lemol)(国外医学·流行病学传染病学分册),2001,28(1):10-15.
[2] GRAEME M. The emerging roles of non-nucleoside reverse transcriptase inhibitors in antiretroviral therapy[J]. Drugs,2001,61(1): 19-26.
[3] JULIE C A,STUART N. Efavirenz[J]. Drugs,1998,56(6): 1055-1064.
[4] GRAEME M,BRIAN G. Current knowledge and future prospects for the use of HIV protease inhibitors[J]. Drugs,1996,51(5): 701-712
[5] GREG L P,DAVID P F. Tipranavir[J]. Drugs,2003,63(15): 1611-1618.
[6] KILBY J M. Potent suppression of HIV-1 replication in humans by T-20,a peptide inhibitor of gp41-mediated virus entry[J]. Nat Med,1998,4(11): 1302-1307.
[7] KETAS T J,FRANK I,KLASSE P J,et al. Human immunodeficiency virus types 1 attachment,coreceptor,and fusion inhibitors are active against both direct and trans infection of primary cells[J]. J Virol,2003,77(4):2762-2767.
[8] OLSON W C,KETAS T,NAGASHIMA K,et al. Potent,broad-spectrum inhibition of HIV-1 by the CCR5 antibody PRO 140[C]. Toronto:Intersci Conf Antimicrob Agents Chemother,2000. Sep 17-20,40. 283.
[9] SCOZZAFAVA A,MASTROLORENZO A,SUPURAN C T. Non-peptidic chemokine receptors antagonists as emerging anti-HIV agents[J]. J Enzym Inhib Med Chem,2002,17(2):69-76.
[10] OWEN S M,RUDOLPH D,SCHOLS D,et al. Susceptibility of diverse primary HIV isolates with varying co-receptor specificity′s to CXCR4 antagonistic compounds[J]. J Med Virol,2002,68(2):147-155.
[11] TIM I,CAROLINE M P. Lamivudine/zidovudine/avacavir triple combination tablet[J]. Drugs,2003,63(11): 1089-1098.
[12] QI J C. Development and application of anti-AIDS drugs[J]. Chin Pharm Inf(中国制药信息),2003,19(4):11-17.
[13] ZHOU Y,XI Y X. Status and advance of vaccine used in children[J]. China Prescri Drug (中国处方药),2 (35):34-38.
[14] MARGARET J,JORGE H. Progress in HIV vaccine development[J]. Curr Opin Pharmacol,2001,1:504-510.
[15] FOUSSAT A,BOUCHET-DELBOS L,COUDERC J,et al. Effects of exogenous IL-2 administration on the homeostasis of CD4+ T lymphocytes[J]. J Clin Immunol,2004,24(5):503-514.
[16] MARSILI G,BORSETTI A,SGARBANTI M,et al. On the role of interferon regulatory factors in HIV-1 replication[J]. Ann NY Acad Sci,2003,1010:29-42.
[17] BALZATINI J,KARLSSON A,PEREZ-PEREZ,et al. Knocking-out concentration of HIV-1-specific inhibitors completely suppress HIV-1 infection and prevent the emergence of drug-resistant virus[J]. Virology,1993,196:576-585.
[18] RONG L F,QIN D A. Liposome: an ideal carrier of anti-HIV drugs[J]. Chem Life(生命的化学),1998,18(1):41-42.
[19] KHAWLA A,LUCILA G D,ROBERT L. Preparation and evaluation of sustained release AZT-Loaded microspheres: optimization of the release characteristics using response surface methodology[J]. J Pharm Sci,1996,85(2):144-149.
[20] KHAWLA A,LUCILA T,D ROBERT L. In vivo evaluation of zidovudine (AZT) -loaded ethylcellulose microspheres after oral administration in Beagle dogs[J]. J Pharm Sci,1997,86(5):554-559.
[21] TARUN K M,SRINI T. Preparation of biodegradable microcapsules of zidovudine using solvent evaporation: Effect of the modification of aqueous phase[J]. Int J Pharm,1996,137:187-197.
[22] O′HAGAN D T,SRINI M,KAZZAZ J,et al. Synergistic adjuvant activity of immunostimulatory DNA and oil/water emulsions for immunization with HIV p55 gag antigen[J]. Vaccine,2002,20(27-28):3389-3398.
[23] CHIANG C C,MARK L,PRAVEEN T,et al. Formulation development of an oral desage form for an HIV protease inhibitor,AG1284[J]. Int J Pharm,1995,117:197-207.
[24] PHILIPS N C,TSOUKAS C. Liposomal encapsulation of azidothymidine result in decreased hematopoletic toxicity and enhanced activity against murine acquired immunodeficiency syndrome[J]. Blood,1992,79:1137-1143.
[25] OUSSOREN C,MAGNANI M,FRATERNALE A,et al. Liposomes as carriers of the antiretroviral agent dideoxycytidine-5′-triphosphate[J]. Int J Pharm,1999,180:261-270.
[26] KONOPKA K,PRETZER E,PLOWMAN B,et al. Long-term noncytopathic productive infection of the human monocytic leukemia cell line THP-1 by human immunodeficiency virus type 1 (HIV-1ⅢB)[J]. Virology,1993,193:877-887.
[27] DUZGUNES N,FLASHER D,PRETZER E,et al. Liposome-mediated therapy of human immunodeficiency virus type-1 and mycobacterium infections[J]. J Lipo Res,1995,5:669-691.
[28] ROPERT C,LAVIGNON M,DUBERNET C,et al. Oligonucleotides encapsulated in pH sensitive liposomes are efficient toward Friend retrovirus[J]. Biochem Biophys Res Commun,1992,183:879-885.
[29] GAGNE J F,DESORMEAUX A. Targeted Delivery of indinavir to HIV-1 primary reservoirs with immunoliposomes[J]. Biochem Biophys Acta,2002,1558(2):198-210.
[30] KONOPKA K,DUZGUNES N,ROSSI J,et al. Receptor ligand-facilitated cationic liposome delivery of anti-HIV-1 Rev binding aptamer and ribozyme DNAs[J]. J Drug Target,1998,5:247-259.
[31] SLEPUSHKIN V A,SINOES S,DAZIN P,et al. Targeting of liposomes to HIV-infected cells by peptides derived from the CD4 receptor[J]. Biochem Biophs Res Commun,1996,227:827-833.
[32] WANG X,ZHENG Y T,RONG L F,et al. Effects of galactosylceramide liposomes on HIV-1 infectivity[J]. Immunol J(免疫学杂志),2002,18(2):128-131.
[33] AHMAD N,KHAN M A,OWAIS M. Liposome mediated antigen dilivery leads to induction of CD8+ T lymphocyte and antibody responses against the V3 loop region of HIVgp120[J]. Immunology,2001,210(1):49-55.
[34] DEVALINA L,ERIC A S,KENNAN C M,et al. Ritonavir-PEG 8000 amorphous solid dispersions: in vitro and in vivo evaluations[J]. J Pharm Sci,2004,93(3):563-569.
[35] PARK J,LEE S,KIM A . Microparticle and liquid formulation of a novel HIV protease inhibitor[J]. Pharm Dev Technol,2002,7(3):297-303.
[36] BOUDAD H,LEGRAND P,LEBAS G,et al. Combined hydroxypropyl-β-cyclodextrin and poly (alkylcyanoacrylate) nanoparticles intended for oral administration of saquinavir[J]. Int J Pharm,2001,218:113-124.
[37] WEARLEY L,CHIEN Y W. Aids and chemotherapy[J]. Drugs Today,1989,25:19-25.
[38] DAE-DUK K,YIE W C. Transdermal delivery of dideoxynucleoside-type anti-HIV drugs. 2. The effect of vehicle and enhancer on shin permeation[J]. J Pharm Sci,1996,85(2):214-219.
[39] SUNIL T K N,RAMESH P. Transdermal delivery of zidovudine: effect of terpenes and their mechanism of action[J]. J Controlled Release,2004,95:367-379.
[40] TEN R M,ANDERSON P M,ZEIN N N,et al. Interleukin-2 liposomes for primary immune deficiency usine the aerosol route[J].Int Immunopharmacol ,2002,2(2-3):333-344.
[41] WINTERQERST U,ROLINSKI B,BOGNER J R,et al. Pharmacokinetics of Zidovudine after rectal administration in human immunodeficiency virus-infected patients[J]. Antimicrob Agents Chemothe,1997,41(5):1143-1145.
{{custom_fnGroup.title_cn}}
脚注
{{custom_fn.content}}
基金
国家自然科学基金资助项目(30371694)
{{custom_fund}}