摘要
目的简要介绍天然来源的人类免疫缺陷病毒1(HIV-1)整合酶抑制剂以及几个研究热点化合物的性质、特点和构效关系。方法以国内外的研究为依据,对HIV-1整合酶的天然抑制剂进行分类综述,简要介绍几个研究热点化合物的性质、特点和构效关系。结果与结论根据化学结构,将HIV-1整合酶的天然抑制剂分为酮类、酚类、生物碱类、萜类以及蛋白和多肽类。以天然抑制剂及现有合成药物的结构特征和活性为指导,通过化学改造,有望获得更有效乃至选择性更强的HIV-1整合酶抑制剂。
关键词
人类免疫缺陷病毒 /
整合酶 /
抑制剂 /
天然化合物
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田仁荣;刘迺发;郑永唐.
天然来源的人类免疫缺陷病毒1整合酶抑制剂[J]. 中国药学杂志, 2006, 41(17): 1281-1285
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脚注
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基金
“十五”国家科技攻关计划(2004BA719A14);国家高技术研究发展计划(2003AA219142);中国科学院知识创新工程(KSCX2-SW-216;KSCX1-SW-11);云南省科技攻关计划(2004NG12)资助课题
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