摘要
目的综述透明质酸寡糖(oligosaccharides of hyaluronan,简称o-HA)的制备、分析方法以及其生物活性。方法查阅近年文献,进行整理归纳。结果o-HA制备时先用透明质酸酶、硫酸软骨素酶进行降解,再经阴离子交换色谱柱(ACE)等方法进行分离纯化,o-HA的生物活性有促血管生成、促进创伤愈合等。结论单糖残基数不同的o-HA生物活性可能不同;用不同酶降解产生的o-HA,即使单糖残基数相同其活性也可能不同。
关键词
透明质酸寡糖 /
酶水解
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崔向珍;王凤山;刘爱华;郭学平.
透明质酸寡糖研究进展[J]. 中国药学杂志, 2006, 41(13): 964-967
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