摘要
目的研究温里药胡椒配伍对活血药当归效应成分阿魏酸生物利用度的影响,探讨活血温里复方的药物配伍机制。方法将温里药胡椒与活血药当归配伍后灌胃小鼠,采用RP-HPLC测定当归胡椒复方在小鼠血浆中阿魏酸的血药浓度,以单用当归为对照,计算复方中阿魏酸的相对生物利用度。结果阿魏酸在小鼠体内的药动学过程符合一室模型,温里药胡椒与活血药当归配伍后,当归胡椒复方中阿魏酸的平均相对生物利用度为169.03%。胡椒复方与单药当归ρmax,AUC0～∞存在差异(P<0.05),而tmax无差异(P>0.05)。结论温里药胡椒与活血药当归配伍,能提高当归主要效应成分阿魏酸的生物利用度,从复方效应成分生物利用度的角度揭示了活血温里复方配伍的科学内涵。
Abstract
OBJECTIVE To study the pharmacokinetics and relative bioavailability of combination Angelica sinensis(Oliv.) Diels and Piper nigrum L..METHODS The content of ferulic acid in plasma was determined directly by HPLC after an oral administration of Piper nigrum L.in combination individually with Angelica sinensis(Oliv.) Diels.The plasma concentration-time curves were plotted.The main pharmacokinetic parameters and relative bioavailability were obtained.RESULTS The plasma concentration-time curve of Ferulic acid was discribed by an one-compartment model.The relative bioavailability of Piper nigrum L.combined with Angelica sinensis Diels was 169.03%.CONCLUSION By the statistical analysis,Piper nigrum L.combined with Angelica sinensis(Oliv.) Diels can increase the relative bioavailability of Ferulic acid.
关键词
胡椒 /
当归 /
阿魏酸 /
相对生物利用度 /
高效液相色谱法
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Key words
Piper nigrum /
Angelica sinensis /
ferulic acid /
relative bioavailability /
HPLC
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杨祖贻;裴瑾;刘荣敏;程佳;万德光;胡荣.
胡椒配伍提高当归效应成分阿魏酸生物利用度的研究[J]. 中国药学杂志, 2006, 41(08): 577-579
YNG Zu-yi;PEI Jin;LIU Rong-min;CHENG Ji;WN De-gung;HU Rong.
Effects of Piper nigrum on Relative Bioavailability of Ferulic Acid in Angelica sinensis[J]. Chinese Pharmaceutical Journal, 2006, 41(08): 577-579
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参考文献
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[4]YANG Z Y,PEI J,LIU R M,et al.Study on enhancing bioavailability of paeoniflorin by combined use with chinese herbs for inner-warming[J]. Chin J Integr Tradit West Med(中国中西医结合杂志)2005，25(9)：822-824.
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脚注
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基金
国家中医药管理局科研基金资助项目(02-03ZP50);四川省中医管理局科研基金资助项目(200217)
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