OBJECTIVE To investigate the feasibility of ethosome gel as transdermal carries of ethinyl estradiol(EE).METHODS EE was encapsulated in ethosomes composed of phospholipid and ethanol,then ethosomes were incorporated in carbopol gel.Percutaneous permeation of EE was observed using human skin and TK-6H transdermal diffusion device in vitro.The concentrations of EE in receptor compartment at specified time points were determined by HPLC. The steady flux and the accumulation quantity of ethinyl estradiol in skin were calculated.RESULTS The flux of EE from ethosome gel was 3.59 μg·cm-2·h-1,which were 9.97,1.69 and 1.45 times higher than that from saturated aqueous solution,30% ethanol solution,gel preparation (contain ethanol 30%),respectively.The subsequence of retention amount in the skin after 24 h was: ethosome gel > 30% ethanol solution > gel> drug-saturated aqueous solution.CONCLUSION Ethosome gel is effective for transdermal delivery and increased the EE amount retained in the skin.
LIU Xio-yu;RO Yue-feng;LING Wen-qun.
Study on Transdermal Penetration of Ethinyl Estradiol Ethosome Gel [J]. Chinese Pharmaceutical Journal, 2006, 41(04): 284-286
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