OBJECTIVE To investigate the effect of Yiqi Mingmu solution on retinal injury of rats induced by ischemia reperfusion injury.METHODS All SD rats were divided into four groups randomly.Retinal ischemia reperfusion was induced by raising the intraocular pressure for 60 min via an intrachameral catheter in rats.Different doses of Yiqi Mingmu solution were respectively given 7 d before ischemia.The rats in normal and model control group were treated with saline.At 1,3,7 and 15 d after the ischemia reperfusion injury,the change of electroretinogram(ERG) a and b wave were observed.RESULTS The difference of the average amplitude of ERG a and b wave was not significant between left eyes and right eyes in the normal group.The average amplitude of ERG a and b wave gradually decreased after the ischemia reperfusion injury in the model control group.Yiqi Mingmu solution owned protective effect on the decrease of ERG a wave after rat retina ischemia reperfusion injury.High dose of Yiqi Mingmu solution had protective effect on the decrease of ERG b wave after rat retina ischemia reperfusion injury.CONCLUSION Yiqi Mingmu solution has protective effect on rat retina ischemia reperfusion injury.
TNG Xi-ln;WNG Yn-dong;WU Wei;HUNG Chu-long.
Effects of Yiqi Mingmu Solution on Electroretinogram in Retina Ischemia Reperfusion Injury Rats [J]. Chinese Pharmaceutical Journal, 2006, 41(04): 269-271
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