摘要
目的探讨人参皂苷Rg1的鼻腔吸收、冰片的促进吸收作用及对鼻腔纤毛的毒性。方法采用在体蟾蜍上腭法研究药物对纤毛运动的影响;采用大鼠在体鼻腔循环法研究人参皂苷Rg1鼻腔吸收的特性及冰片对其吸收的影响;采用扫描电镜观察人参皂苷Rg1及冰片对大鼠鼻腔纤毛的急性毒性。结果循环液中人参皂苷Rg1的含量为100,250,500 mg·L-1时,鼻腔的吸收速度常数分别为0.000 30,0.000 40和0.000 7 min-1。循环液中含有10 g·L-1,2%和3%的冰片时,对250 mg·L-1的人参皂苷Rg1吸收速度常数分别为0.001 9,0.001 2和0.001 3 min-1。结论人参皂苷Rg1能通过鼻腔黏膜吸收,对纤毛无毒,10 g·L-1的冰片对其吸收有促进作用。
Abstract
OBJECTIVE To investigate the nasal absorption of ginsenoside Rg1 and the absorption enhancen effect of borneol.METHODS The effect of ginsenoside Rg1 and borneol on cililary movement were evaluated by in situ toad palate model.Nasal circulatory perfusion test in vivo was employed to investigate the characteristics of nasal mucosa absorption ginsenoside Rg1 in rats.The electron microscope scanning technique was used to evaluate the nasal ciliotoxicity of ginsenoside Rg1 and borneol on the nasal mucosas of the rats.RESULTS When the concentrations of ginsenoside Rg1 were 100,250,500 mg·L-1,respectively,the corresponding values of the absorption rate were 0.000 30,0.000 40 and 0.000 7 min-1.However,when the concentration of ginsenoside Rg1 was 250 mg·L-1in circulation liquid,the absorption rates were 0.001 9,0.001 2 and 0.001 3 min-1 with the aid of borneol of 10,20 and 30 g·L-1.CONCLUSION Ginsenoside Rg1 can be absorbed through the nasal mucous and borneol can enhance the absorption.The Ginsenoside Rg1 spray has no damage to the nasal mucosas of rats.
关键词
人参皂苷Rg1 /
冰片 /
鼻腔吸收 /
纤毛毒性
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Key words
ginsenoside Rg1 /
borneol /
nasal absorption /
nasal ciliotoxicity
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陈新梅;朱家壁;孙卫东;张立建.
冰片对人参皂苷Rg1鼻腔吸收的促进作用及鼻腔纤毛毒性研究[J]. 中国药学杂志, 2006, 41(04): 261-264
CHEN Xin-mei;ZHU Ji-i;SUN Wei-dong;ZHNG Li-jin.
Effect of Absorption Enhancer of Borneol on Ginsenoside Rg1 and the Nasal Ciliotoxicity [J]. Chinese Pharmaceutical Journal, 2006, 41(04): 261-264
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脚注
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