1. Shanghai Institute of Materia Medica， Shanghai Institutes for Biological Sciences，Chinese Academy of Sciences， Shanghai 201203，China； 2. Topfond Pharmaceutical Inc.， Zhumadian 463000，China
OBJECTIVE To study the activity of coumarins as PDE5 inhibitor.METHODS The coumarins were extracted with 95% alcohol from Cnidium monnieri(L.) Cusson and with CHCl3 from Angelica dahurica Benth.et Hook.,and then isolated via column chromatog-raphy and HPLC. After structure identification, the inhibition of compounds on PDE5 was investigated according to the existing methods. RESULTS 8 compounds were isolated and identified, and 4 compounds were obtained by structure modification. The activities data as PDE5 inhibitors were tested. CONCLUSION Osthol showes the potent inhibitation on PDE5.
WEI Xio-hui;ZHNG Shu-jun;XI Gung-xin;FU Shou;WNG Wei;SHEN Jing-shn;JI Ru-yun.
Inhibitation of Coumarins in Cnidium monnieri Cusson and Angelian dahuricn on PDE5 [J]. Chinese Pharmaceutical Journal, 2006, 41(02): 100-101
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
参考文献
[1] FUJILKA T，FURUMI K，FUJII H，et al.Antiproliferative constituents from Umbelliferae Plants.V.a new furanocoumarin and falcarindiol furanocoumarin ethers from the root of Angelica japonica[J] .Chem Pharm Bull，1999，47 (1)：96-100.
[2] STANELY W L，WAISS A C，LUNDIN R E，et al.Auraptenol，a coumarin compound in bitter (Seville) orange oil[J] .Tetrahedron，1965，21(1)：89-92.
[3] WU T S，FURUKAWA H.Acridone alkaloids.VII.constituents of Citrus sinensis Osbeck var.brasiliensis Tanaka.isolation and characterization of three new acridone alkaloids，and a new coumarin[J] .Chem Pharm Bull，1983，31(3)：901-906.
[4] PHILIP C S，MONIQUE S J S，MARIANNE A Y，et al.Insect antifeedant furanocoumarins from Tetradium daniellii[J] .Phytochemistry，2003，63：41-46.
[5] LEE K H，SOINE T O，COUMARINS X.Spectral studies on some linear furanocoumarins[J] .J Pharm Sci，1969，58 (6)： 681-683.
[6] MASUDA T，TAKASUGI M，ANETAI M.Psoralen and other linear furanocoumarins as phytoalexins in Glehnia Littoralis[J] .Phytochemistry，1998，47 (1)： 13-16.
[7] LEE K H，SOINE T O，COUMARINS I X.Coumarins of Sphenosciadium capitellatum(A.Gray)[J] .J Pharm Sci，1969，58 (6)： 675-681.
[8] GELLERT M，SZENDREI K，NOVAK I，et al.Furocoumarins from the pericarps of Evodia hupehensis[J] .Phytochemistry，1972，11： 2894.
[9] AGRAWAL A，SIDDIQUI I R，SINGH J.Coumarins from the roots of Feronia limonia[J] .Phytochemisty，1989，28 (4)： 1229-1231.
[10] RAZDAN T K，KACHROO V，HAKAR S，et al.Furanocoumarins from Heracleum canescens[J] .Phytochemistry，1982，21 (4)：923-927.
[11] KIM D K，LEE N，LEE J Y，et al.Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues[J] .Bioorg Med Chem，2001，9(6)： 1609-1610.
