目的介绍不同聚合物支架在组织工程中的研究进展。方法着重比较了采用PLGA(poly lactide-co-glycolide)等聚合物材料制备组织工程支架几种方法的特点以及支架体内外效应的研究。结果与结论随着新的聚合物骨架材料和骨架制备方法研究的日渐成熟,组织工程学将在促进人类健康和疾病治疗中发挥愈来愈重要的作用。
关键词
组织工程 /
PLGA /
聚合物骨架
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参考文献
[1]Langer R,Vacanti J. Tissue engineering[J]. Science,1993,260:920.
[2]Lanza RP, Langer R,Vacanti J. Principles of Tissue Engineering[M]. Vol 2.New York:Academic Press. 2000:251-252.
[3]Singh L, Kumar V,Ratner BD. Generation of porous microcellular 85/15 poly (DL-lactide-co-glycolide) foams for biomedical applications[J]. Biomaterials,2004, 25(13):2611.
[4]王彦平. 生物可降解性组织工程支架材料的制备[J]. 甘肃科技, 2003,19(12):30.
[5]Lu LC, Peter SJ, Lyman MD, et al. In vitro degradation of porous poly(L-lactic acid) foams [J]. Biomaterials, 2000,21(15):1595.
[6]Lu LC, Peter SJ, Lyman MD, et al. In vitro and in vivo degradation of porous poly(DL-lactic-co-glycolic acid) foams[J]. Biomaterials,2000,21(18):1837.
[7]Thomson RC, Mikos AG, Beahm E, et al. Guided tissue fabrication from periosteum using preformed biodegradable polymer scaffolds [J]. Biomaterials,1999,20(21):2007.
[8]Liao CJ,Chen CF,Chen JH,et al. Fabrication of porous biodegradable polymer scaffolds using a solvent merging/particulate leaching method[J]. J Biomed Mater Res,2002,59(4):676.
[9]罗丙红,全大萍,廖凯荣,等. PLGA组织工程支架的构建及降解行为研究[J]. 中山大学学报(自然科学版),2003,42(2):46.
[10]Hu YH, Grainger DW, Winn SR,et al. Fabrication of poly(α-hydroxy acid) foam scaffolds using multiple solvent systems[J]. J Biomed Mater Res,2002,59(3):563.
[11]Nam YS,Park TG. Porous biodegradable polymeric scaffolds prepared by thermally induced phase separation[J]. J Biomed Mater Res, 1999,47:8.
[12]Whang K, Thomas CH, Healy KE. A novel method to fabricate biodegradable scaffolds[J]. Polymer,1995,6:837.
[13]Han MJ. Biodegradable membranes for the controlled release of progesterone. 1. Characterization of membrane morphologies coagulated from PLGA/Progesterone/DMF solutions[J]. J Appl Polym Sci,2000,75:60.
[14]Boccaccini AR, Stamboulis AG, Rashid A, et al. Composite surgical sutures with bioactive glas coating[J].J Biomed Mater Res B Appl Biomater,2003,67(1):618.
[15]Nam YS, Park TG. Biodegradable polymeric microcellular foams by modified thermally induced phase separation method [J]. Biomaterials,1999,20(19):1783.
[16]Mooney DJ,Baldwin DF, Suh NP, et al. Novel approach to fabricate porous sponges of poly(D, L-lactic-co-glycolic acid) without the use of organic solvents[J]. Biomaterials,1996,17:1417.
[17]Sheridan MH, Shea LD, Peters MC, et al. Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery [J]. J Controlled Rel,2000,64(2):91.
[18]Leathese DH, Kim BS, Mooney DJ. Open pore biodegradable matrices formed with gas foaming[J]. J Biomed Mater Res,1998,42:396.
[19]Buchko CJ,Chen LC,Shen Y,et al. Processing and microstructural characterization of porous biocompatible protein polymer thin films Polymer[J]. Polymer,1999,40:7397.
[20]Kim K, Yu M, Zong XH, et al. Control of degradation rate and hydrophilicity in electrospun non-woven poly(D,L-lactide) nanofiber scaffolds for biomedical applications[J]. Biomaterials,2003,24(27):4977.
[21]Doshi J, Reneker DH. Electrospinning process and applications of electrospun fibers[J]. J Electrost,1995,35(2):151.
[22]Luu YK, Kim K, Hsiao BS, et al. Development of a nanostructured DNA delivery scaffold via electrospinning of PLGA and PLA–PEG block copolymers[J]. J Controlled Release,2003,89(2):341.
[23]Ho MH, Kuo PY, Hsieh HJ, et al. Preparation of porous scaffolds by using freeze-extraction and freeze-gelation methods[J]. Biomaterials,2004,25(1):129.
[24]Babensee JE, Anderson JM, Melntire LV,et al. Host response to tissue engineered devices[J]. Adv Drug Deliv Rev,1998,33:111.
[25]van Tienen TG, Heijkants RGJC, Buma P,et al. Tissue ingrowth and degradation of two biodegradable porous polymers with different porosities and pore sizes[J]. Biomaterials,2002,23(8):1731.
[26]Wu LB,Ding JD. In vitro degradation of three-dimensional porous poly(D,L-lactide-co-glycolide) scaffolds for tissue engineering [J]. Biomaterials,2004,25(27):5821.
[27]赵瑾,袁晓燕,姚康德. 组织工程多孔支架制备技术进展[J]. 化工进展,2002,21(9):644.
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