摘要
目的研究小剂量甲氨蝶呤(MTX)治疗异位妊娠的药动学。方法12例异位妊娠患者肌注MTX20mg。于给药前和给药后0.17,0.5,1,2,3,4,6,8,12和24h抽取静脉血,采用荧光偏振免疫分析法(FPIA)测定MTX血药浓度。用3P97软件计算其药动学参数。结果小剂量肌注MTX符合开放二室动力学模型。结论此研究结果有助于甲氨蝶呤合理应用,为临床用药提供理论依据。
Abstract
OBJECTIVE To investigate the pharmacokinetic parameters of low-dose methotrexate in the treatment of ectopic pregnancy. METHODS After a single intramuscular admintration of methotrexate 20 mg was given to 12 patients with ectopic pregnancy, the serum samples were collected from 0 to 24 h. MTX concentration in serum was measured by fluorescence polarization immunoassay(FPIA) .The pharmacokinetic parameter were calculated with 3P97 program software. RESULTS The pharmacokinetic profile of low-dose metholrexate in patients with ectopic pregnancy was described by a two-compartment open model. CONCLUSION These results may be helpful to a rational individualized methodtrexate dosage regimen.
关键词
甲氨蝶呤 /
药动学 /
异位妊娠
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Key words
methotrexate /
pharmacokinetics /
ectopic pregnancy
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梁健健;王娟;吕军;俞丽萍.
小剂量甲氨蝶呤治疗异位妊娠的药动学研究[J]. 中国药学杂志, 2005, 39(13): 1034-1035
LING Jin-jin;WNG Jun;L Jun;YU Li-ping.
Pharmacokinetics of low-dose methotrexate in treatment of ectopic pregnancy [J]. Chinese Pharmaceutical Journal, 2005, 39(13): 1034-1035
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参考文献
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[7］彭健，姚敏元.大剂量甲氨喋呤治疗儿童急性淋巴细胞白血病的药代动力学.中国药房，1996，7(2)：77.
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脚注
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基金
广东省医学科学技术研究基金课题(2001)
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