[1］Cunliffe WJ, Caputo R, Dreno B, et al.Clinical efficacy and safety comparison of adapalene gel and tretinoin gel in the treatment of acne vulgaris:Europe and U.S multicenter trials[J］.Am Acad Dermatol, 1997,36:S126. [2］Cunliffe WJ, Caputo R, Dreno B, et al. Efficacy and safety comparison of adapalene (CD271) gel and tretinoin gel in the topical treatment of acne vulgaris：a Europe multicenter trial [J］.Dermatol Treat, 1997,8:173. [3］刘文英.药物分析[M］.第5版.北京:人民卫生出版社,2003:80～84. [4］中国药典2000年版. 第二部[S］. 2000:33.