摘要
目的研究5-O-[(3,4-亚甲二氧基)-肉桂酰基]-奎宁酸甲酯的合成工艺。方法以(3,4-亚甲二氧基)-肉桂酰氯和奎宁酸为原料经5步反应制得本品。并对本品进行鸭乙肝病毒2215细胞体外抗病毒试验。结果得到的样品经NMR和MS分析为结构正确的化合物,本品抗乙肝病毒作用明显。结论5-O-[(3,4-亚甲二氧基)-肉桂酰基]-奎宁酸甲酯为一新的化合物,有可能成为治疗乙型肝炎的新药或先导化合物。
Abstract
OBJECTIVE To synthesize 5-O-[(3,4-methylenedioxy)-cinnamoyl]-quinic acid methyl ester. METHODS The target compound was obtained after five steps reaction from caffetyl choloride and (3,4-methylenedioxy)-cinnamoyl acid, the inhibition on the excretion of HBsAg was investigated.RESULTS The structure of synthesized product was confirmed by NMR and MS, it showed obvious inhibition excretion of HBsAg.CONCLUSION The target compound was a new compound, it had the same activity as 5-O-caffetyl-quinic acid ethyl ester.
关键词
5-O-[(3 /
4-亚甲二氧基)-肉桂酰基]-奎宁酸甲酯 /
合成 /
HBsAg
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Key words
5-0-[(3 /
4-methylenedioxy)-cinnamoyl]-quinic acid methyl ester /
synthesis /
HBsAg /
inhibition excretion of HbsAg
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田景奎;陈世智;邹忠梅;徐丽珍;杨世林.
5-0-[(3,4-亚甲二氧基)-肉桂酰基]-奎宁酸甲酯的合成[J]. 中国药学杂志, 2005, 39(10): 788-790
TIN Jing-kui;CHEN Shi-zhi;ZOU Zhong-mei;XU Li-zhen;YNG Shi-lin.
Synthesis of 5-O-[(3,4-methylenedioxy)-cinnamoyl]-quinic acid methyl ester [J]. Chinese Pharmaceutical Journal, 2005, 39(10): 788-790
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参考文献
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脚注
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基金
国家自然科学基金资助项目(39870085)国家“九五”攻关课题(969010637)
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