摘要
目的建立吡哌酸片剂溶出度的光纤传感实时检测方法。方法采用转篮法,转速100r·min-1,以稀盐酸(24→1000)为溶出介质,用光纤化学传感药物溶出度实时分析系统在320nm处检测紫外吸收。同时用药典规定方法检测溶出浓度,以作相互对照。结果在50.～249μg·mL-1内,吸光度与吡哌酸片的浓度成线性关系,平均回收率为100.4%。光纤传感实时检测方法所得结果与药典方法结果无显著性差异(P>0.05)。结论所建立的吡哌酸片剂溶出度的光纤传感实时检测方法可行,在位在线、连续定量地反映了药物体外溶出特性。
Abstract
OBJECTIVE To develop a fiber optic chemical sensor dissolution test system (FOCSDT) for determining the dissolution of pipemidic acid tablets.METHODS The drug dissolution concentration was detected using the FOCSDT system, and the detection wavelength was at 320 nm. RESULTS A good linearity was obtained over the range of 50.5～249 μg·mL-1. The average recovery rate was 100.4 % (n=6).The results obtained from the FOCSDT were no significantly different from the methods published in Chinese Pharmacopeia (2000) (P>0.05). CONCLUSION The new method established for the dissolution test of pipemidic acid tablets is feasible.As a procession analysis, FOCSDT system showed the real dissolution of drug and provided the total information.
关键词
光纤传感 /
吡哌酸 /
药物溶出度
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Key words
fiber optical chemistry sensor /
pipemidic acid /
drug dissolution
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李莉;陈坚;李新霞;张力;邹华.
吡哌酸片溶出度光纤传感实时分析研究[J]. 中国药学杂志, 2005, 39(10): 786-787
LI Li;CHEN Jin;LI Xin-xi;ZHNG Li;ZOU Hu.
Study on dissolution of pipemidic acid tablets by fiber optic chemical sensor dissolution test system [J]. Chinese Pharmaceutical Journal, 2005, 39(10): 786-787
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参考文献
[1］Kevin CB， Erik K， John P，et al.In situ dissolution testing using a UV fiber optic probe dissolution system[J］.Dissolution Technologies， 1999， 6 (4)：11.
[2］Kevin B， Kurt R， Abe K， et al. Analytical performance of a fiber optic probe dissolution system[J］.Dissolution Technologies， 2001，8(4)：13.
[3］Kevin B， Kurt R， Abe K，et al. In situ fiber-optic-baseed spectrometric measurement for USP dissolution test[J］.Dissolution Technologies，2001，8(1)：8.
[4］陈坚. 基于多猝灭响应原理的PBA光纤化学膜传感器的性能和应用研究[J］.中国科学(C)，1997，27(1)：69.
[5］陈坚.基于多猝灭响应原理的光纤化学传感器及其在药物分析领域应用的研究[J］.药物分析杂志，1995，15：411.
[6］郭炬亮，陈坚.用光纤化学传感器连续在位监测呋喃托因肠溶片的体外溶出度[J］.药物分析杂志，1997，17(4)：228.
[7］朱滨，陈坚.用光纤化学传感器连续在位监测甲硝唑片剂的体外溶出度[J］.药学学报，1994，29(5)：369.
[8］Li W，Chen J，Xiang B，et al. Simultaneous on-line dissolution monitoring of multicomponent solid preparations containing vitamins B1， B2 and B6 by a fiber-optic sensor system[J］.Anal Chim Acta，2000，408：39.
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脚注
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基金
新疆自治区高技术发展计划资助项目(200311110)新疆自治区中小企业创新基金资助(CXJ2002-10)
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