目的研究白芷镇痛的有效成分。方法运用柱色谱、制备型薄层色谱等方法对白芷镇痛的有效部位进行了分离;测定理化常数和波谱数据鉴定结构。结果从白芷根中分离并鉴定了12个成分,分别为异欧前胡素(Ⅰ)、欧前胡素(Ⅱ)、东莨菪内酯(Ⅲ)、白当归素(Ⅳ)、白当归脑(Ⅴ)、茴芹内酯(Ⅵ)、蛇床子素(Ⅶ)、8-甲氧基补骨脂素(Ⅷ)、ethanethioamick(Ⅸ)、β-谷甾醇(Ⅹ)、水合氧化前胡素(Ⅺ)、东莨菪苷(Ⅻ)。结论ethanethioamide为首次从伞形科植物中分得;茴芹内酯为首次从当归属植物中分得;东莨菪苷、8-甲氧基补骨脂素、β-谷甾醇为首次从杭白芷中分得。

OBJECTIVE To study the analgesic constituents in Angelica dahurica(Fisch. ex Hoffm.)Benth. et Hook. f. var.formosana(Boiss.) Shan et Yuan. METHODS The active compounds were isolated by chromatography and identified by IR, NMR and MS. RESULTS: 12 compounds were isolated from A. dahurica(Fisch. ex Hoffm.)Benth. et Hook. f. var. formosana( Boiss.) Shan et Yuan and identified as isoimperatorin(Ⅰ), imperatorin(Ⅱ) , scopoletin( Ⅲ), byakangelicin (Ⅳ), byakangelicol(Ⅴ), pimpinellin(Ⅵ), osthol(Ⅶ),8-methoxypsoralen (Ⅷ) , ethanethioamide (Ⅸ),β-sitosterol (Ⅹ) , oxypeucedanin hydrate (Ⅺ) and scopolin (Ⅻ ) . CONCLUSION Ethanethioamide was firstly isolated from Umbelifera plants. Pimpinellin was firstly found in the Angelica species. Scopolin,β-sitosterol and 8- methoxypsoralen were all isolated from A.dahurica(Fisch.ex Hoffm.)Benth. et Hook. f. var. formosana(Boiss.)Shan et Yuan for the first time.