目的 采用高效液相色谱法测定克林霉素磷酸酯栓中克林霉素磷酸酯的含量。方法 用SymmetryShield C₁₈柱（5 μm,250 mm×4.6 mm），以乙腈-枸橼酸溶液（取枸橼酸1.05 g，加水溶成1 000 mL，即得）（22∶78）为流动相，用紫外检测器于210 nm处检测。结果 线性范围为99.36～149.04 μg·mL^-1（r=0.999?7）。平均回收率为101.2%，RSD=0.25%（n=3）。结论 本法操作简便,分析准确快速，干扰小。

OBJECTIVE A HPLC method was established for the determination of clindamycin phophate for clindamycin phophate suppositories METHODS Clindamycin phophate was separated on Symmetry Shield C₁₈ column (5μm, 250 mm×4.6 mm) with citric acid solution (citric acid 1.05 g dissolved in water and diluted to 1 000 mL)-acetonitrile (78∶22) as the mobile phase and detected at 210 nm. The flow rate was 1.0 mL·min^-1 RESULTS The standard curve was linear over the concentration range of 99.36～149.04 μg·mL^-1 and the correlation coefficient was 0.999 7. The average recovery and the relative standard deviation was 101.2%， and 0.25% respectively CONCLUSION The method is simple, rapid, accurate and reliable.