目的 考察含有0.9%氯化钠和5%葡萄糖的3种材质输液容器对15种药物的吸着性。方法 将一定量的15种药品分别加入含有100 mL或250 mL 0.9%氯化钠和(或)5%葡萄糖的M312非PVC输液袋、玻璃输液瓶和PVC输液袋中，于混匀后的0，1，3，24及48 h取样，采用高效液相色谱法测定药物浓度。结果 48 h相对0 h的药物含量百分数:①在PVC输液袋中，胰岛素、硝酸异山梨酯、硝酸甘油和地西泮在13.28%～68.83%之间；②在玻璃输液瓶中，硝酸异山梨酯和硝酸甘油在70.72%～76.22%之间，香丹注射液中的原儿茶醛下降百分数小于12%；除水溶液中不稳定药物外，其他药物下降百分数小于7%；③在M312输液袋中，除水溶液中不稳定药物外，其他药物下降百分数小于8%。结论 PVC输液袋及玻璃输液瓶对一些药物有吸着，临床使用这些药物时应避免选用该材质；若不能避免选用，应考虑适当增加剂量。

OBJECTIVE To investigate the losses of fifteen injectable drugs from aqueous solutions (0.9% sodium chloride and 5% dextrose) stored in M312 Non-PVC infusion bags (NPVC), glass bottles (G) and PVC infusion bags (PVC) respectively for 48 hours and compare their sorption characteristics METHODS Each drug was separately added to above infusion bags or bottles containing 100 mL or 250 mL of 0.9% sodium chloride and 5% dextrose respectively. Samples of drug solutions were collected at 0，1，3，24，48 hours and analyzed by HPLC methods RESULTS The remaining contents of insulin, isosorbide dinitrate, nitroglycerin and diazepam in 0.9% sodium chloride and/or 5% dextrose in PVC at 48 hours were 68.83% and 65.72%, 58.69% and 47.77%, 40.84% and 33.65% and 13.28%, respectively. The remaining contents of isosorbide dinitrate and nitroglycerin in G were 76.22% and 72.17%, 74.17% and 70.72%, respectively. No significant adsorption of the other drugs to the surface of G or NPVC was found (loss<7% and 8% respectively). Cefotaxime and cefradine were not stable in aqueous solutions CONCLUSION PVC and/or G should not be used with insulin, isosorbide dinitrate, nitroglycerin and diazepam. If there are no other choices, addition of extra drug to compensate for the losses is suggested.