目的 对中药瓜蒌进行有机氯农药的残留量测定，开展瓜蒌质量标准的规范化研究。方法 采用气相色谱法对六六六（BHC）4种异构体、滴滴涕（DDT）4种异构体和五氯硝基苯(PCNB)进行测定。结果 11个瓜蒌样品中六六六的总含量位于2.86～21.85 μg·kg^-1的范围，滴滴涕的总含量位于2.86～50.04 μg·kg^-1的范围，五氯硝基苯的含量低于4.94 μg·kg^-1。结论 所测瓜蒌中农药残留量低于我国国家相关的规定限量；样品中商品瓜蒌的农药残留量高于非商品瓜蒌的残留量，提示我们在瓜蒌的贮存、运输等过程中应该限制农药的污染。

OBJECTIVE To determine the residues of organochlorine pesticide in Fructus Trichosanthis, in order to develop the quality standards of Fructus Trichosanthis METHODS The residues of 4 isomers of benzene hexachloride (BHC), 4 isomers of dichloro-diphenyl trichloroethane (DDT) and pentachloro nitrobenzene (PCNB) were determined by gas chromatography RESULTS The residue contents of total BHC, total DDT and PCNB were 2.86～21.85, 2.86～50.04 and below 4.94 μg·kg^-1 respectively CONCLUSION The residues of organochlorine pesticide in Fructus Trichosanthis were lower than the permissible maximum limits of our national standard. The organochlorine pesticide residues in commercial samples were higher than that in crude drugs. It is suggested that we should try to avoid some pollution of organochlorine pesticides in the course of storage and transportation.