PPAR配体作用机制及新配体筛选研究进展

葛恒;王长谦

中国药学杂志 ›› 2004, Vol. 39 ›› Issue (03) : 170-172.

中国药学杂志 ›› 2004, Vol. 39 ›› Issue (03) : 170-172.
综述

PPAR配体作用机制及新配体筛选研究进展

  • 葛恒;王长谦
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摘要

目的 介绍过氧化酶体增殖剂激活受体(PPAR)的配体作用机制及其新配体的筛选。方法 Medline检索最近5年关于PPAR与配体结合机制及新配体的研究的文献。结果与结论 PPAR各亚型配体结合区的结构差异以及与不同协同因子的相互作用可能是造成PPAR各亚型与配体特异性的主要原因,而已建立的一系列实验方法为筛选或合成新的PPAR高效配体提供了可能。

关键词

PPAR / 配体 / 筛选试验

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葛恒;王长谦. PPAR配体作用机制及新配体筛选研究进展[J]. 中国药学杂志, 2004, 39(03): 170-172

参考文献

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