目的测定利福平及氯诺昔康中有机溶剂残留量。方法毛细管气相色谱柱顶空进样法，FID检测器。利福平以5%苯基甲基聚硅氧烷为固定相，柱温50℃；氯诺昔康以聚乙二醇为固定相，柱温50℃维持15min,以10℃·min^-1的速率升温至165℃,维持5min。结果甲醇、丙酮、氯仿、正丁醇线性关系r分别为0.9999，0.9999，0.9984，0.9998;平均回收率分别为96.0%，97.3%，81.1%，93.9%,RSD分别为2.7%，1.9%，8.8%，2.5%(n=5)。结论方法柱效高、灵敏、准确，适用于利福平及氯诺昔康中有机溶剂残留量测定。

OBJECTIVE To determine the residual organic volatile solvents in rifampin and lornoxicam.METHOD S The samples were injected on sillica capillary column by headspace sampler with FID detector.The determination of rifampin was performed on a HP5 5% phenyl methyl siloxane.The column temperature was 50℃.The determination of lornoxicam was performed on a AC 20 polyethylene glycol column which was kept the initial temperature at 50℃,then raised to 165℃ at the rate of 10℃·min^-1 and sustained for 5 min.RESULTS The correlation r in methanol,acetone,chloroform and butanol was respectively 0.999 9,0.999 9,0.998 4 and 0.999 8.The recovery was 96.0%,97.3%,81.1% and 93.9% with RSD 2.7%,1.9%,8.8% and 2.5%,(n=5) respectively.CONCLUSION The method appeared to be sensitive and accurate,and can be used for the determination of the residual organic volatile solvents in rifampin and lornoxicam.