目的从圆滑番荔枝树皮提取分离活性化合物。方法95%乙醇提取、溶剂萃取、硅胶柱色谱、重结晶等，根据IR,MS,NMR等光谱技术和化学方法鉴定化合物的结构。结果分离到5个化合物，分别鉴定为ent-16α-hydro-kauran-17-oic acid (Ⅰ)、annonebinide B(ent-16α-hydro-kauran-19-oic acid-17-yl ent-16β-kauran-17-oate)(Ⅱ) 、ent-kauran-16α,17-diol(Ⅲ)、4α-hydroxy-19-nor-ent-kauran-17-oic acid (Ⅳ) 、liriodenine(Ⅴ)。结论Ⅱ为新化合物。
Abstract
OBJECTIVE The bio-active constituents were expected to be obtained from Annona glabra Linn.METHOD S It was extracted with 95% alcohol,distributed by different solvents,isolated via column chromatography on silica gel and purified by crystallization.The structures of the constituents were identified by means of IR,MS,NMR and chemical methods respectively.RESULTS Five compounds were isolated and elucidated as ent-16α-hydro-kauran-17-oic acid(Ⅰ),annonebinide B(ent-16α-hydro-kauran-19-oic acid-17-yl ent-16β-kauran-17-oate) (Ⅱ),ent-kauran-16α,17-diol(Ⅲ),4α-hydroxy-19-nor-ent-kauran-17-oic acid (Ⅳ) and liriodenine(Ⅴ),respectively.CONCLUSION The compound Ⅱ was found for the first time.
关键词
圆滑番荔枝 /
贝壳杉烷 /
二萜 /
生物碱
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Key words
Annona glabra /
kaurane /
diterpenoid /
alkaloid
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参考文献
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