目的 为了增加阿昔洛韦在皮肤中的滞留量，提高局部生物利用度，制备了阿昔洛韦棕榈酸酯脂质体凝胶剂。研究其质量控制，进行稳定性考察。方法 采用均匀设计法筛选最佳处方，以Sephadex G-50柱测定脂质体的包封率和制剂的渗漏率，观察脂质体的外观形态。结果 脂质体凝胶剂为乳白色，脂质体平均包封率为95.1%，平均粒径为300nm，对光、湿度稳定性好，但受温度影响较大。结论 该脂质体凝胶剂制备工艺可行，质量稳定，检测方法可靠，可满足临床需要。

OBJECTIVE To prepare the acyclovir ACV)palmitate liposome gel in order to raise ACV concentration in the skin and enhance the topical bioavailability of ACV. METHOD The optimum formation was selected by means of an uniform design.Both the embedding ratio of liposome and the leaking ratio of the preparation were determined.The appearance of liposome was observed. RESULTS The latex white liposome gel was prepared.The mean embedding ratio was 95.1%,and the mean diameter was 300 nm.The preparation was stable to light and humidity,but was intable to heat. CONCLUSION The ACV palmitate liposome gel was practicable with stable quality.Its determination method was reliable.