人参皂苷对胃肠肿瘤敏感性测定的实验研究

邢建华;仲崇斐;王晓洁

中国药学杂志 ›› 2000, Vol. 35 ›› Issue (04) : 273-275.

中国药学杂志 ›› 2000, Vol. 35 ›› Issue (04) : 273-275.
药物与临床

人参皂苷对胃肠肿瘤敏感性测定的实验研究

  • 邢建华;仲崇斐;王晓洁
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An experimental study of ginsenoside sensitivity to gastrointestinal tumor

  • Xing Jianhua
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摘要

目的:研究人参皂苷对胃癌细胞、大肠病细胞的作用。方法:采用噻唑蓝(MTT)比色法浏定胃癌38例、大肠癌40例癌细胞时人参皂苷及8种常用化疗药物的敬感性。结果:人参皂苷对大肠疮敏感,对胃痛不敏感,其作用明显低于5-氟脲嘧啶、丝裂霉素、平阳霉素、咪替派、足叶乙苷。结论:人参皂苷可用于配合其它化疗药辅助治疗肠癌及胃癌。

Abstract

OBJECTIVE: To study the effect of ginsenoside to the gastrocolic cancer cells. METHODS: The drug sensitivity to the cancer tissues from 38 cases of gastric carcinoma and 40 cases of colonic carcinoma has been made with a method of thiazole blue the determination (MTT).The drug sensitivity test involved ginsenoside and 8 kinds of common chemotherapeutic agents. RESULTS: Ginsenoside to colonic carcinoma was more sensitive in comparison with the gastric carcinoma.Its effect was obviously low than 5FU(fluorouracil),DDP(cis diaminedichloroplatin),MMC(mitomycine),PYM(ping yang mycin),TSPA(triethylenethiophosphoramide),VP16(vepeside). CONCLUSION: Ginsenoside as a adjuvant can be combined with some chemotherapeutic agents for the treatments of gastric and colonic carcinoma.

关键词

人参皂苷 / 胃痛细胞 / 大肠癌细胞 / MTT比色法

Key words

ginsenoside / gastric cancer cell / colonic cancer cell / method of thiazole blue determination(MTT)

引用本文

导出引用
邢建华;仲崇斐;王晓洁. 人参皂苷对胃肠肿瘤敏感性测定的实验研究[J]. 中国药学杂志, 2000, 35(04): 273-275
Xing Jinhu . An experimental study of ginsenoside sensitivity to gastrointestinal tumor[J]. Chinese Pharmaceutical Journal, 2000, 35(04): 273-275

参考文献

[1]王本祥.人参茎叶和花皂苷抗肿瘤作用的研究.中成药,1989,11(2):27. [2]曲慧敬,张恩宁,岳彤华,等.人恶性肿瘤细胞体外对砒霜敏感性的MTT比色法实验研究.烟台医学,1998,26(3):10. [3]李向高.人参的抗肿瘤作用.中成药研究,1982,(11):1. [4]贾林森,王淑兰,李淑莲,等.人参茎叶皂甙对体外培养胃癌细胞的影响.白求恩医科大学学报,1992,18:1. [5]韩萍.含人参皂苷Rg3的药物可选择性地抑制瘤细胞.国外医药·植物药分册,1994,9(2):89.

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