摘要
目的:研究人参皂苷对胃癌细胞、大肠病细胞的作用。方法:采用噻唑蓝(MTT)比色法浏定胃癌38例、大肠癌40例癌细胞时人参皂苷及8种常用化疗药物的敬感性。结果:人参皂苷对大肠疮敏感,对胃痛不敏感,其作用明显低于5-氟脲嘧啶、丝裂霉素、平阳霉素、咪替派、足叶乙苷。结论:人参皂苷可用于配合其它化疗药辅助治疗肠癌及胃癌。
Abstract
OBJECTIVE: To study the effect of ginsenoside to the gastrocolic cancer cells. METHODS: The drug sensitivity to the cancer tissues from 38 cases of gastric carcinoma and 40 cases of colonic carcinoma has been made with a method of thiazole blue the determination (MTT).The drug sensitivity test involved ginsenoside and 8 kinds of common chemotherapeutic agents. RESULTS: Ginsenoside to colonic carcinoma was more sensitive in comparison with the gastric carcinoma.Its effect was obviously low than 5FU(fluorouracil),DDP(cis diaminedichloroplatin),MMC(mitomycine),PYM(ping yang mycin),TSPA(triethylenethiophosphoramide),VP16(vepeside). CONCLUSION: Ginsenoside as a adjuvant can be combined with some chemotherapeutic agents for the treatments of gastric and colonic carcinoma.
关键词
人参皂苷 /
胃痛细胞 /
大肠癌细胞 /
MTT比色法
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Key words
ginsenoside /
gastric cancer cell /
colonic cancer cell /
method of thiazole blue determination(MTT)
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邢建华;仲崇斐;王晓洁.
人参皂苷对胃肠肿瘤敏感性测定的实验研究[J]. 中国药学杂志, 2000, 35(04): 273-275
Xing Jinhu .
An experimental study of ginsenoside sensitivity to gastrointestinal tumor[J]. Chinese Pharmaceutical Journal, 2000, 35(04): 273-275
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参考文献
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脚注
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