Acid dye spectrophotometry method for drug content and determination of dissolution of phencynonate hydrochloride tablets
Wang Weixian
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(Wang WX),Gao Lijun (Gao LJ),Yang Zaoping (Yang ZP
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文章历史+
收稿日期
出版日期
1998-06-29
2000-04-05
发布日期
2000-04-05
摘要
目的:测定盐酸苯环壬酯片的含量及溶出度。方法:采用浓剂萃取、酸性色素比色法测定含量,检测波长413 nm。溶出度以转篮法测定,转速100 r·min-1,溶出介质500 ml pH 3磷酸盐缓冲液。结果:3.0~15.0μg·ml-1范围内线性良好,r=0.9999(n=5),平均回收率99.95%(n=9),RSD为土0.65%。片剂30 min定时取样测定,主药溶出90%以上。结论:方法简便、准确、专属,可作为该制剂的含量浏定和质量控制。
Abstract
OBJECTIVE: To determine the content and dissolution of phencynonate hydrochloride tablets (PHT). METHODS: A solvent extractionacid dye spectrophotometry method was used with the detection wavelength at 413 nm.A basker method was used to study the dissolution,the rotative velocity was 100 r·min-1and the solvent was 500 ml of phosphate buffer solution (pH 3). RESULTS: The linear range of the standard curve was 3.0~15.0 μg·ml-1,r=0.9999,n=5.The average recovery of assay was 99.95% with a relative standard deviation of 0.65% (n=9).The drug dissolution rate for 30 min was over 90%. CONCLUSION: This method is convenient,accurate and specific for the content determination of PHT.
Wng Weixin .
Acid dye spectrophotometry method for drug content and determination of dissolution of phencynonate hydrochloride tablets[J]. Chinese Pharmaceutical Journal, 2000, 35(04): 265-267