头孢吡肟治疗院内获得性肺炎疗效评价

高德伟;刘春雷;张进川;王华琼

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (09) : 624-625.

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (09) : 624-625.
药物与临床

头孢吡肟治疗院内获得性肺炎疗效评价

  • 高德伟;刘春雷;张进川;王华琼
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Observation of the therapeutic effcet of cefepime in the treatment of nosocomial pneumonia

  • Gao Dewei
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摘要

目的:评价头孢吡肟治疗院内获得性肺炎的临床疗效。方法:42例患者,包括治疗组18例和对照组24例,分别应用头孢吡肟和头孢他啶,剂量为2g/次,bid,均为静脉给药,疗程8~10d。结果:头孢吡肟和头孢他啶的临床有效率分别为94.4%和91.4%,细菌清除率为90.9%和78.9%,无明显不良反应。结论:头孢吡肟和头孢他啶均为治疗院内获得性肺炎有效和安全的抗生素。

Abstract

OBJECTIVE:To evaluate the efficacy of Cefepime in the treatment of nosocomial pneumonia.METHODS:Forty-two patients were prospectively randomized to receive Cefepime (18 patients)or ceftazidime (24 patients).Antibiotics in both the test and the control groups were given intravenously with the dosage of 2g every 12 hours for 8~10days.RESULTS:The overall efficacy rate of Cefepime and ceftazidime were 94.4% and 91.4% respectively.The bacterial clearance rate were 90.9% and 78.9% respcetively.CONCLUSION:Cefepime and ceftazidime were safe and potent antibacterial agents in the treatment of nosocomial pneumonia.

关键词

头孢吡肟 / 院内获得性肺炎

Key words

cefepime / nosocomial pneumonia

引用本文

导出引用
高德伟;刘春雷;张进川;王华琼. 头孢吡肟治疗院内获得性肺炎疗效评价[J]. 中国药学杂志, 1999, 34(09): 624-625
Go Dewei. Observation of the therapeutic effcet of cefepime in the treatment of nosocomial pneumonia[J]. Chinese Pharmaceutical Journal, 1999, 34(09): 624-625

参考文献

1 潘启超.第四代头孢菌素-头孢派姆.中国新药杂志,1998,7(2):89. 2 Neu H.Safety of cefepime:a new entended-spectrum parenteral cephalosporim.Am J Med,1996,100(Suppl.6A):68. 3 Edelstein H,Chirurgi V,Oster S,et al.A randomized trial of cefepime(BMY 28142)and ceftazidime for the treatment of pneumonia,J Antimicrob Chemother,1991,28(4):569. 4 Thornsbverry C,Yee YC.Comparative activety of eight antimicrobial agents against clinical bacterial isolates from the united states measured by two methods.Am J Med,1996,100(Suppl.6A):26. 5 Sanfers W E,Tenney JH,Lessler RE.Efficacy of cefepime in the treatment of infections due to multiply resistant enterobacter species.Clin Infect Dis,1996,23(3):454. 6 Schrank JH,Kelly JW,McAllister CK.Randomized cpmparison of cefepime and ceftazidime for treatment of Hospitalized patients with Gram-Negative B acteremia.Clin Infect Dis,1995,20(1):56.

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