目的:研究雷公滕醋酸乙酯提取物 (TWEE)对大鼠肾上腺的刺激作用。方法:给大鼠连续30d TWEEMpo(25mg·kg^-1bid),并设置泼尼松组和对照组,分别测定血清皮质酮含量、观察肾上腺组织学及超微结构变化。结果:给药30d后,TWEE组血清皮质酮含量明显升高;肾上腺皮质明显增厚,束状带细胞胞浆充满类脂质空泡;电镜观察束状带细胞胞浆中富含线粒体、光面内质网及大小不等的脂滴,线粒体嵴呈空泡状。结论:TWEE能促进大鼠肾上腺皮质增生及促进皮质束状带细胞分泌皮质酮。

OBJECTIVE:To observe the stimulant effects of ethylacetate extract ofTripterygium wilfordii(TWEE) on adrenal cortex in rat.METHOD:Oral administration of TWEE 25mg·kg^-1.bid were given to SD rats for 30 days.The serum corticosterone was determined and the histology,ultrastructure of adrenal glands were observed.RESULTS:After 30 days administration,the serum corticosterone level was markedly increased in the TWEE group.The fascicular zone in adrenal cortex markedly became thick and the plasma filled with lipoid vesicles.The cell plasma of fascicular zone contained a great deal of mitochondria,smooth endoplasmic reticulum and lipid droplets observed by transmission electron microscopy.The cristae of mitochondria were vacuolar.CONCLUSION:TWEE can promote the production of corticosterone and the proliferation of the cell of fascicular zone in adrenal cortex in SD rat.