脑缺血的细胞应答对研制新药的启示

蒲小平;李长龄

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (09) : 579-582.

中国药学杂志 ›› 1999, Vol. 34 ›› Issue (09) : 579-582.
综述

脑缺血的细胞应答对研制新药的启示

  • 蒲小平;李长龄
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摘要

目的:脑缺血的有关细胞应答的研究近几年在国外已越来越受到重视,本文主要介绍国内外的缺血再灌流的分子药理学研究的最新动态。方法:通过综述国内外有关脑缺血再灌流研究的资料,分为5个方面进行综述。结果:脑缺血再灌流新模型能用于抗脑缺血脑保护剂的新药研究,脑缺血引起微循环障碍及多种基因表达变化。结论:阐明脑缺血的分子机制,可为研制抗脑缺血药物提供新思路,新方法。

关键词

脑缺血模型 / 微循环 / 应激蛋白 / 凋亡 / 诱导型一氧化氮合成酶 / 抗脑缺血药

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蒲小平;李长龄. 脑缺血的细胞应答对研制新药的启示[J]. 中国药学杂志, 1999, 34(09): 579-582

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