目的：建立精密、快速简便地测定复方氯丙那林片中盐酸氯丙那林、盐酸去氯羟嗪及盐酸溴己新3种成分含量的方法。方法：采用毛细管区带电泳法(capilary zone electrophoresis,CZE)，以0.05mol·L^-1(pH3.0)磷酸盐缓冲液作运行液，分离电压18kV(运行电流100μA～110μA)。结果：3种成分在8min～15min之内完全达到基线分离，各组分溶液浓度在40μg·ml^-1～240μg·ml^-1范围内，浓度与峰面积之间呈良好的线性关系。选用甲氧苄氨嘧啶(TMP)作内标物，可准确测定3种成分的含量，批内(RSD)均小于1.2%(n=9)，3种成分的加样回收率不低于99.5%，RSD均小于1.1%(n=5)。结论：用CZE进行复方氯丙那林片中3种成分的含量测定，准确可靠、方便易行，而药品标准中规定的方法只能定性，不能进行含量测定。

OBJECTIVE: To study a method for determination of three components, clorprenaline hydrocloride, bromhexine hydrocloride and decloxizine hydroxloride in compound clorprenaline tablet. METHOD: A capillary zone electrophoresis (CZE) method was used to assay three components of this compound preparation. The complete separation of components was achieved with 0.05 mol·L^-1 pH 3.0 running phosphate buffer and a constant voltage of 18 kV (current of 100 μA～110 μA). RESULTS: The retention times of individual components were between eight and fifteen minutes and a good linearity was shown between concentrations and peak areas in the concentration range over 40 μg·ml^-1～240 μg·ml ^-1 . Using trimethoprim as internal standard. The relative standard deviation (RSD) of each component determined in a batch was less than 1.2% (n=9). The recovery of each component was not less than 99.5% with RSD less than 1.1% (n=5). CONCLUSION: This method is accurate, simple and rapid. The quantity of each three components may be determined using this method. The three components were only identified by the standard method.