摘要
目的：为研究毫微粒给药系统质量评价，拓宽阿克拉霉素A毫微粒的制剂学内容，制备了阿克拉霉素A聚乳酸毫微粒。方法：采用均匀设计方法设计实验，以界面聚合法制备出阿克拉霉素Ａ聚乳酸毫微粒。结果：得到的毫微粒平均粒径为80nm，平均载药量为18.5%，平均包封率为86.7%。结论：以聚乳酸为载体材料，制备阿克拉霉素A聚乳酸毫微粒的工艺是可行的。
Abstract
OBJECTIVE: To prepare the poly (DL-lactide) aclacinomycin nanoparticle in order to evaluate the nanoparticle delivery system and to develop the pharmaceutics of aclacinomycin nanoparticle. METHODS: An optimal design was selected to establish the optimal condition, and the interfacial polymerization method was used to prepare the nanoparticle system. RESULTS: The mean diameter of the nanoparticle was 80 nm, the mean drug loading was 18.5%, and the drug embedding ratio was 86.7%. CONCLUSION: The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle is practicable and successful.
关键词
阿克拉霉素A /
聚乳酸 /
毫微粒
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Key words
aclacinomycin A /
poly (DL-lactide) /
nanoparticle
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何林;蒋学华;李芚.
阿克拉霉素A聚乳酸毫微粒的制备工艺研究[J]. 中国药学杂志, 1998, 33(05): 289-291
He Lin.
The technology of preparation of poly (DL-lactide) aclacinomycin nanoparticle[J]. Chinese Pharmaceutical Journal, 1998, 33(05): 289-291
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参考文献
1 蒋学华，廖工铁，李瑞雪，等．阿克拉霉素聚氰基丙烯酸异丁酯毫微粒制备条件优化．华西药学杂志，1993，8(3)：127．
2 蒋学华，廖工铁，姚情，等．吸附法制备阿克拉霉素A聚氰基丙烯酸异丁酯毫微粒的研究．中国药学杂志，1995，30 (5)：274．
3 Fessi H，Puisieux F，Devissaguet JP，et al．Nanocapsule formation by interfacial polymer deposition following solvent displacement Int J Pharm，1989，55：R1．
4 Guterres SS，Fessi H，Barratt JP，et al．Poly(DL-lactide) nanocapsule containing diclofenac：Ⅰ．Formulation and stability study，Int J Pharm，1995，113：57．
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脚注
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基金
国家自然科学基金资助项目第39570842号
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