目的：对毛梗-莶(Siegesbeckiaglabrescens)的化学成分进行分离、鉴定研究。方法：采用各种层析色谱技术进行分离。从毛梗莶中分离到了5个化合物，用IR，MS，₁H-NMR,₁₃C-NMR和₂D-NMR光谱鉴定化合物。结果：经光谱鉴定化合物为(Ⅰ)对映16β，17二羟基-贝壳杉-19-羧酸(ent-16β,17-dihydroxykauran-19-oicacid),化合物(Ⅱ)为单棕榈酸甘油脂(glyceralmon/opalmitate)，化合物(Ⅲ)为对映贝壳杉-16β，17，18-三醇(ent-kauran-16β，17，18-triol)，化合物(Ⅳ)为18-羟基-贝壳杉-16-烯-19-羧酸(18-hydroxy-hauran-16-en-19-oicacid)，化合物(Ⅴ)为胡萝卜苷(Daucosterol)。结论：化合物(Ⅰ)、(Ⅱ)、(Ⅲ)为首次从该植物中得到。

OBJECTIVE: To investigate the chemical constituents from the herbs of Siegesbeckia glabrescens. METHODS: To isolate chemical constituent. We used the solvent extration together with column chromatography. IR, MS, NMR and chemical methods were used to determine the structure of the isolated constituents. RESULTS: In five constituents obtained, the sturctures were elucidated as ent-16β, 17-dihydroxykaurna-19-oic acid(Ⅰ), glycerol monopalmitate(Ⅱ) , ent-kauran-16β,17,18-triol(Ⅲ) , 18-hydroxykauran-16-en-19-oic acid(Ⅳ)and daucosterol(Ⅴ). CONCLUSION: Compounds of(Ⅰ) ～ (Ⅲ)were separated from S. glabrescens for the first time, and compounds of(Ⅰ) ,(Ⅲ)and(Ⅳ)belong to diterpenes.