钙拮抗剂延缓衰老的作用

温宝书;张敏;白生华

中国药学杂志 ›› 1998, Vol. 33 ›› Issue (05) : 265-268.

中国药学杂志 ›› 1998, Vol. 33 ›› Issue (05) : 265-268.
综述

钙拮抗剂延缓衰老的作用

  • 温宝书; 张敏; 白生华
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摘要

目的:介绍国内外有关神经细胞老化的发生与钙离子调控能力的关系以及钙拮抗剂用于抗衰老研究的最新进展。方法:根据国内外大量有代表性的研究成果,结合自己工作实践,进一步分析、整理和归纳。结果:脑老化是伴随着神经细胞内钙稳态的失调和细胞钙调节能力降低而发生。钙拮抗剂可阻断细胞外钙内流,促进细胞内钙库摄钙,维持细胞内钙平衡;并可改善脑细胞结构,增加脑血流量,保证细胞的营养供应。结论:钙拮抗剂用于延缓衰老的研究为探索老年病的发病机制以及老年病的针对性治疗提供了新思路。

关键词

钙拮抗剂 / 老化 / 线粒体 / 内质网 / Ryanodine受体

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温宝书;张敏;白生华. 钙拮抗剂延缓衰老的作用[J]. 中国药学杂志, 1998, 33(05): 265-268

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