摘要
目的：研究齐酞酸钠对大鼠实验性肝损伤的保护作用，并与齐墩果酸进行量效比较。方法：采用化学毒物D-氨基半乳糖和四氯化碳致大鼠肝脏损伤，测定生化指标及观察病理组织学改变。结果：齐酞酸钠呈剂量依赖性地明显降低D-氨基半乳糖、四氯化碳引起的大鼠血清丙氨酸转移酶(ALT)增高；显著减轻肝脏中脂肪蓄积；病理组织学检查齐酞酸钠明显减轻肝细胞的变性和坏死。结论：齐酞酸钠对大鼠实验性肝损伤有明显的保护作用，在同等剂量下上述作用优于齐墩果酸。
Abstract
OBJECTIVE: To investigate the protective effects of OLA-PENa on experimental hepatic injury in rats and compare it with OLA in the doseresponse relationships. METHODS: Biochemical indexes and histopathological examination of hepatic injury in rats caused by toxicant chemicals D-galactosamine (D-Galn) and CCl4] were determined. RESULTS: OLA-PENa obviously inhibited the rising of serum alanine transaminase (ALT) caused by D-Galn and CCl4 and dramatically decreased liver fat storage as well in a dosedependent manner. Histopathological examination showed that OLA-PENa can evidently alleviate the condition of the degeneration of hepatic cells and that of necrosis. CONCLUSION: The protective effects of OLA-PENa on experimental liver injury in rats, all the mentioned effects, are more powerful than those of OLA with the same dosage.
关键词
齐酞酸钠 /
实验性肝损伤
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Key words
OLA-PENa (oleanolic acid 3β phthalic monoester disodium salt) /
experimental hepatic injury
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宛蕾;陈秀芬;蒋朝晖.
齐酞酸钠对大鼠实验性肝损伤的保护作用[J]. 中国药学杂志, 1998, 33(02): 80-83
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The protective effects of OLA-PENa on experimental liver injury in rats[J]. Chinese Pharmaceutical Journal, 1998, 33(02): 80-83
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参考文献
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脚注
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基金
贵州省科学技术基金资助课题，黔基合计字(1990)3102号
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