目的：优化西替考马的合成路线、简化操作方法和提高反应产率。方法：通过改变反应起始物，重新设计反应路线。特别是利用2，2二甲基-3-苯基-7-甲氧基苯并吡喃(2)中的双键和苯酚进行Friedel-Crafts烷基化反应。结果：以五步反应获到最终产物。其中在Friedel-Crafts烷基化反应中高选择性的获得反式异构体，总收率达40%。结论：避免了文献报道中的高压氢化和构型转化两个反应单元，简化了合成路线并提高了反应产率。

OBJECTIVE: To improve the synthesis and promote the yield for centchroman. METHODS: The reported synthetic route was simplified and redesigned, especially using 2, 2-dimethyl-3-phenyl-7-methoxychromene (2) to react with phenol. RESULTS: The transisomer was got in the step of highly stereo-selective Friedel-Crafts alkylation and final product centchroman was got just by five steps with over all yield of 40%. CONCLUSION: The synthesis for centchroman was simplified and yield was increased with out two steps of hydrogenation in high pressure and configuration transformation which appeared in the reported route.