烷化剂引起的DNA损伤与细胞周期和细胞凋亡的关系

孙俊;

中国药学杂志 ›› 1997, Vol. 32 ›› Issue (07) : 393-397.

中国药学杂志 ›› 1997, Vol. 32 ›› Issue (07) : 393-397.
综述

烷化剂引起的DNA损伤与细胞周期和细胞凋亡的关系

  • 孙俊;
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摘要

目的:介绍烷化剂的药理作用与细胞周期和细胞凋亡的关系,为有效地将烷化剂应用于临床治疗及研制开发新的烷化剂提供理论依据。方法:查阅近年有关烷化剂与细胞周期和细胞凋亡研究的文献20余篇。结果:从烷化剂与细胞周期的关系、烷化剂引起的细胞凋亡及癌基因表达调控几个方面进行纷述。结论:研究烷化剂引起的DNA损伤与细胞周期、细胞凋亡的关系,从新的角度证实用化学药物治疗肿瘤有深入的理论基拙,可在多方面为肿瘤化疗的发展带来转机。

关键词

杭癌药物 / 烷化剂 / 细胞周期 / 细胞凋亡

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导出引用
孙俊;. 烷化剂引起的DNA损伤与细胞周期和细胞凋亡的关系[J]. 中国药学杂志, 1997, 32(07): 393-397

参考文献

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