目的:设计研究一种治疗口腔厌氧菌感染制剂的处方和制备工艺，建立制剂的含量测定方法，并对其稳定性进行初步探讨。方法:参照类似产品设计处方，双波长等吸收点法测定含量，加速试验法考查稳定性。结果:产品口惑较好，替硝唑(TN)的含量可于波长317 nm处直接测定，醋酸氯己定(CA)可于波长254 nm，波长273 nm处用双波长等吸收点法测定含贡，测定浓度低于10 mg·L^-1时其收率较好，3个月的稳定性试验结果显示降解率分别为5.93%,7.30%。结论:制剂口惑好，含量测定方法简便可靠，稳定性符合要求，临床疗效有待于验证。

OBJECTIVE: To use a gargle to treat anaerobic and other bacterial infection of oral cavity. METHODS:Dual-wavelength isobestic point spctrophotometry was used as the quantitative analysis method. Joel-Dvis method was used to study the stability. RESULTS: The content of tinidazol (TN ) was detected in wave length 317 nm directory Chlorhexidine acetate(CA) was assayed in wave length 254 nm and wave length 273 nm using dual-wavelength isobestic point spctrophotometry. Good recovery was noted when the detective concentration was less than 10 mg·L^-1. The degration ratio of TN and CA was 5.95%and 7.30% respectively after 3-month stability test. CONCLUSION: The preparation's taste, quantitative analysis and stability are well acceptable. The clinical efficacy will be verified in the next study.