目的：了解抗病毒药更昔洛韦静脉注射后在家兔体内的药动学特性。方法：采用高效液相色谱法浏定药物在兔血、尿、组织中浓度的经时变化。结果：家兔静注3种荆童更昔洛韦后血药浓度变化符合开放式三房室模型特征。消除半衰期1.7 h。药物在体内分布广泛，肾脏中血药浓度最高。AUC与剂量呈正相关。24 h尿中原型药物排出黄占给药贡的90.8%。结论：更昔洛韦在家兔体内消除较快，无明显蓄积。

OBJECTIVE:The pharmacokinetics of ganciclovir was investigated in rabbits. METHODS:The serum urine and tissues level of ganciclovir was determined by high performance liquid chromatography. RESULTS:The pharmacokinetics of ganciclovir fitted to a three compartment model after iv of 5,10,20 mg/kg ganciclovir respectively. The mean values for maximum concentration of drug in serum were 20, 39，89 pg/ml. The eliminative half-life was 1.7h(1.4~1.8 h). The AUC was 12.94,25.35 and 40.0(pg·h)/ml after iv injection. The distribution of ganciclovir was wide. The level of drug in kidney was higher. We also recovered 90.8% (16.3%)of the administered ganciclovir from the urine as unchanged drug within 24 hours. CONCLUSION;The elimination of Ganciclovir was quickly in rabbits. There is no significant culmulation.