目的：研究po安克干糖浆后羟氛节青霉素与克拉维酸的药动学与生物利用度。方法:未用离子对反相高效液相色语法测定10名健康志愿受试者po安克干糖浆和Augmentin干糖浆后，经氮爷青霉素与克拉维酸在血中浓度变化情况，计算二者的药动学参数、相对生物利用度，并以双单侧t检脸法进行统计分析。结果:二者经氮羊青霉素的药一时数据用统计矩方法处理，达峰时间分别是85.1±5.42 min与83.1±9.88 min,峰浓度分别是10.94±0.72 μg/ml与10.88±0.55 μg/ml，平均滞留时间分别是140.37±12.61 min与131.05土11.06 min,药-时曲线下面积分别是1 566.25±128.47 (μg·min)/ml与1 464.37±115.45 (fig·min)/ml。二者克拉维酸的药-时曲线符合一级吸收的一室模型，达峰时问分别是64.31±4.62 min与63.3±2.76 min,药-时曲线下面积分别是488.56±41.05 (μg·min)/ml与488.96±25.26 (μg·min)/ml，安克干枪浆相对生物利用度径氛节青霉素是108.20%±14.20%，克拉维酸是99.83%±5.10% ,结论：安克干糖浆与Augmentin是生物等效荆。

OBJECTIVE:To study the pharmacokinetics and relative bioavailability of Anke dried syrup. METHODS:The amoxfcillin and clavulanic acid were determined after a single oral dose of Anke dried syrup was given to 10 volunteers in an open randomized cross-over test. AmoRicillin and clavulanic acid concentration in serum were assayed together by ion-pair HPLC method. RESULTS: After taking a single oral dose of Anke dried syrup containing 300 mg amoxicillin and 150 mg clavulamic acid,the c_maxand T_maxof amoxicillin was 10.94±0.72 ug/ml and 85.1±5.42 min respectively, the AUC was 1 566.25±128.47 (μg·min)/ml and the MRT was 140.37±12.61min. The and Tm.of clavulanic acid was 2.85土0.14 fag/ml and 64.31±4.62 min respectively,and the AUC。was 488.56±41.05 (μg·min)/ml. The concentration-time curves of clavulanic acid after medication conformed to an one compartment open model with a first order absorption. The bioavailability of Anke dried syrup was 108.30%±14.20% for amoxicillin and 99.83%±5.10% for clavulanic acid respectively. CONCLUSION : The result of statistical analysis showed that the two formulations were bioequivalent.