新疆膨润土作为药用辅料的可行性研究

邢君芬;陈新梅;李军;敖秉臣

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (S1) : 26-28.

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (S1) : 26-28.
药剂

新疆膨润土作为药用辅料的可行性研究

  • 邢君芬;陈新梅;李军;敖秉臣
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The feasibility of Xinjiang bentonite as a kind of pharmaceutical excipient

  • XING Jun-fen; CHEN Xin-mei ;LI Jun; AO Bing-chen
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摘要

将新疆膨润土纯化后研究了作为药用辅料的可行性。研究结果显示:该膨润土吸水膨胀性强(41.5±5.5倍于自身体积),粘度高(5%水分散液为70±30mPA·s),触变性良好,具一定的吸附性。无毒、无刺激性,铅、砷、汞合量低微(Pb:0.013%,As:0.002%,Hg:0.5μg/L),可望作为新型无机胶体药物辅料应用于各种药物制剂。通过在炉甘石洗剂、AI(OH)3;凝胶剂、阿司匹林片、不着色甲紫霜等剂型中的实际应用,充分证明其优异的助悬、崩解、载体性能,应用前景光明。

Abstract

We studied the feasibility of Xinjiang bentonite as a kind of pharmaceutical excipi- ent after it was purified.The results showed thatthe bentonite had a higher swelling power in wa-ter(41.5±5.5ml).The viscosity of 5%water solution was 70±30mPa·s.It had good thixotropyand certain absorption.The bentonite was free from poison and stimulation,in which the content of Pb.As.Hg elements were tiny(Pb:0.013%.As:0.002%,Hg:2.5μg/L).Therefore.the ben-tonite can be applied into various pharmacies as a new kind of pharmaceutical excipient.Applied into calamin lotion,AI(HO)3 gel,asprin tablet,gentian violet cream etc,the bentonite can be used as an excellent suspending agent,disintgrant,and drug carrier.

关键词

膨润土 / 药用辅料

Key words

bentonite / pharmaceutical excipient

引用本文

导出引用
邢君芬;陈新梅;李军;敖秉臣. 新疆膨润土作为药用辅料的可行性研究[J]. 中国药学杂志, 1994, 29(S1): 26-28
XING Jun-fen;CHEN Xin-mei;LI Jun;O ing-chen. The feasibility of Xinjiang bentonite as a kind of pharmaceutical excipient[J]. Chinese Pharmaceutical Journal, 1994, 29(S1): 26-28

参考文献

1 Geogakonlos PP ,Malamataris S. Locust bean gum granulating and binding agent for tablets.Pharm Ind .1980.42(6):642. 2 Hans Schitt.Controlled flocculation of coarse suspensiousby colloidally dispersed solidel:interaction of bismuth subnitrate with bentonite.J Pharm Sci.1976.65(7):855. 3 Martin.Cook.et al.Reminton’s Practice of Pharmacy twelfih.Mack publishing company,Easton Pennylvania 1061.1329. 4 Sujeev Gulati.Madam AK,Miglani BD.A new technique for sustained realease dosage forms.East pharma.1982.8:207. 5 USPXXI NFXXI:1990. 6 邢君芬.梁迎.敖秉臣 膨润土对药用混悬液助悬性能的考察.中国医院药学杂志.1991.11(2):74. 7 中国药典1990年版(二部).1990:153

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