热分析法研究白障明片的处方组成

苗华;陆彬

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (10) : 616-620.

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (10) : 616-620.
药品质量及检验

热分析法研究白障明片的处方组成

  • 苗华;陆彬
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Thermal analysis studies on formulation composition of tablets of bendazac lysine

  • MAO Hua;LU Bin
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摘要

采用差示扫描量热分析筛选与白障明无相互作用的辅料、片剂处方组成与工艺,改善了白障明的吸湿性。白障明片20min累积溶出度为98.84%±0.64%。白障明与白障明片用热重分析法分别测得热解活化能Ea为116±13kJ/mol与126±7kJ/mol,两者无显著性差异。在37℃、RH75%放置3个月,外观与含量等无变化。

Abstract

Differential scanning colorimetry(DSC) was used to screen out best excipientswhich do not interact with bendazac lysine(BZL).According to the preformulation studies,for-mulation composition and preparation of ordinary tablets have been designed. The humidificationof BZL was improved. The cumulative dissolution in 20min of the tablets was 98. 84%±0. 64%.Using thermogravimetry analysis(TGA ) method the activation energies of thermal degradationwere found to be 116±13(BZL) and 126±7(tablets)kJ/mol,respectively,which are not obviously different.On the other hand,the appearance and the content of the tablets had no change after three months of storage at 37℃ and 75% RH.

关键词

白障明 / 差示扫描量热分析 / 临界相对湿度 / 热重分析

Key words

bendazac lysine / differential scanning colorimetry / critical relative humidity / ther-mograviemetry analysis

引用本文

导出引用
苗华;陆彬. 热分析法研究白障明片的处方组成[J]. 中国药学杂志, 1994, 29(10): 616-620
MO Hu;LU in. Thermal analysis studies on formulation composition of tablets of bendazac lysine[J]. Chinese Pharmaceutical Journal, 1994, 29(10): 616-620

参考文献

1Silvestrini B,Catanese B, Lisciani R,et al.Studies on the mechanism of action of bendazac.Arzneimittelforsch,1970.50:252. 2Sivestrini B,Baiocchi L.Bendazac composition for treatment of cataract.UK Patent Application GB 2110532A.1983-06-22 3潘悌摘。DSC法研究盐酸氧烯洛尔、替马西渊与片剂赋形剂间的相容性[英].国外医学.药学分册,1990,17(6):373. 4金守礼.高分子材料热寿命快速评定方法的基础理论。工程塑料技术,1980,3:28

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