尼群地平注射液的研究

周延安;蔡鸿生;张先洲;尹武华

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (10) : 613-615.

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (10) : 613-615.
药剂

尼群地平注射液的研究

  • 周延安;蔡鸿生;张先洲;尹武华
作者信息 +

Study nitrendipine injection

  • ZHOU Yan-an;CAI Hong-sheng;ZHANG Xian-zhou;YIN Wu-hua
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摘要

本文作者报道了尼群地平注射液的制各及鉴别、含量测定,并对其光、热稳定性进行了研究。结果表明,对光不稳定,热加速试验的E=81.9424kJ·kcal·mol-1,t25℃0.9=2.56年。

Abstract

We studied the preparation,indentification,assay of nitrendipine injection, and itsstability on light and heat.The results showed that nitrendipine was unstable on light. The exper-iment of heat indicated that E=81.-1, t0.925℃=2. 56a.

关键词

尼群地平注射液 / 制备 / 鉴别 / 含量测定

Key words

nitrendipine injection / preparation / identification assay / stability

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导出引用
周延安;蔡鸿生;张先洲;尹武华. 尼群地平注射液的研究[J]. 中国药学杂志, 1994, 29(10): 613-615
ZHOU Yn-n;CI Hong-sheng;ZHNG Xin-zhou;YIN Wu-hu. Study nitrendipine injection[J]. Chinese Pharmaceutical Journal, 1994, 29(10): 613-615

参考文献

1李智培。尼群地平与硝苯啶治疗高血压病的对比分析.中华心血管病杂志,1990:l8(4):240. 2房箴.小剂量尼群地平与硝苯啶降压效果的双盲对比分析.中华心血管病杂志,1990,18(4):267. 3张振刚.尼群地平对高血压病患者左心室舒张功能和心肌肥厚的影响.中华心血管病杂志,1990:18(5):268. 4Stanbrook HS,Morris KG. Nitrendipine reduces acute and chronic hypoxic pulmonary hypertension in rats. J Cardiovas Pharwwcol, 1987 :9(suppl. 4,Ptl~2):S54. 5Scherling D. et al..Biotransformation of nitrendipine in rat,dog,and mouse. Arzneim ForschJDrug Res, 1991;41 (10):1009. 6章丽华.硝苯啶注射液处方设计与评价.药学进展,1989;13(2):42. 7Squella J A. Zanocco A, Perna S,et al. A poiarographic study of the photodegradation of nitrendipine. J Pharm Biomed Anal, 1990;8(1):43. 8饶曼人.尼群地平对麻醉犬冠脉流量、心肌耗氧量、二氧化碳产生率的影响.药学学报.1988>23(2):100.

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