双氯灭痛控释片的释药机理及影响释药的因素

龙晓英;朱小雄;梁超峰

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (09) : 536-539.

中国药学杂志
中国药学杂志 ›› 1994, Vol. 29 ›› Issue (09) : 536-539.
药剂

双氯灭痛控释片的释药机理及影响释药的因素

  • 龙晓英；朱小雄；梁超峰
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Mechanisms of Diclofenac sodium release from controlled-releasetablets and factors affecting release rate

  • LONG Xiao-ying;ZHU Xiao-xiong;LIANG Chao-feng
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摘要

双氯灭痛（DC－Na）亲水凝胶骨架片及不溶性骨架片体外均能控制DC－Na释药12h，亲水凝胶骨架片释药机理符合一级动力学，lg（1－F）＝0．1865－0．1177t，相关系数r＝0．9928，不溶性骨架片释药机理符合Higuchi方程，F=0.3226t?-0.1503,相关系数r＝0．9916，释药递质的pH对DC－Na释药速度没有明显影响，转篮转达为50或100r／min释药速度没有明显变化。

Abstract

Diclofenac sodium can be released continuously from hydrophilic and insolublematrices for more than 12 hours in vitro. The mechanism of hydrophilic matrix is first-orderkinetics,lg(1-F)=0.1865-0.1177t,r=-0.9928 and that of insoluble matrix is the square rootkinetics,F=0. 3226t1/2-0.1503,r=0.9916.Medium pH affects significantly the release rate ofDiclofenal sodium, There is no notable effect in stirring rate between 50 and 100 r/min for therelease rate of Diclofenal sodium.

关键词

亲水凝胶骨架片 / 不溶性骨架片 / 双氯灭痛 / 释药机理

Key words

hydrophilic matrix / insoluble matrix / Dlclofenac sodium / release mechanism

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龙晓英;朱小雄;梁超峰. 双氯灭痛控释片的释药机理及影响释药的因素[J]. 中国药学杂志, 1994, 29(09): 536-539
LONG Xio-ying;ZHU Xio-xiong;LING Cho-feng. Mechanisms of Diclofenac sodium release from controlled-releasetablets and factors affecting release rate[J]. Chinese Pharmaceutical Journal, 1994, 29(09): 536-539

参考文献

1王尔华.双氯灭痛合成工艺评述.药学进展，1989,13(3) :20. 2Wilis JV,Kendall MJ,Jack DB. The influence of food on the absorption of DC-Na after single and multiple oral doses. Eur J Clin Pharmacol 91979,16 :405. 3Kiess W, Scand. The pharmaceutics of DC-Na in man. J Rheumato,l978,22:17. 4何铭新，杨彦新.感冒通中双氯灭痛含量測定.药物分析杂志，1987,7(1)：54. 5Lieberman HA, Lachman L. Pharm Dosage Form, vol 3.edl. New York. Marcel Dekker Ine,1981：160. 6Hguchi T. The mechanism of the drug release fron granules. J Pharm Sci ,1963,52：1145. 7Hatem Fessl,Marty J PjPuist EUXF^et al. Square root of time dependence of matrix formulations with low drug content. J Pharm Sd, 1982,71 (7) * 749. 8Yoshihko Hirotani，Yukio Arakawa9Yoshimi Maeda,et al.Preparation of controlled-release grannies of DC-Na. Chem Pharm 1987,35：3049.

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