环孢素A软膏的处方优选及其体外透皮试验

陆晓和;赵仲坤;卓海通;储小曼;贺建国

中国药学杂志 ›› 1994, Vol. 29 ›› Issue (08) : 473-475.

中国药学杂志
中国药学杂志 ›› 1994, Vol. 29 ›› Issue (08) : 473-475.
药剂

环孢素A软膏的处方优选及其体外透皮试验

  • 陆晓和；赵仲坤；卓海通；储小曼；贺建国
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Ih vitro diffusion in evaluation of various formulations of cyclosporin A

  • LU Xao-he;ZHAO Zong-kun;ZUO Hai-tong;CHU Xao-man;HE Jan-guo1
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摘要

使用改进Franz扩散池对环孢素A软膏进行正交试验优选处方，分别考查了基质类型、助渗剂及环孢素A的药物浓反对制剂主药的释放、渗透及吸收的影响。筛选出的优化处方再用离体人皮进行透皮实验。结果表明，优化处方的环孢素A的透皮可达到有效治疗浓度。

Abstract

Cyclosporin A oitment was prepared with Azone and propane-1,2-diol,Which act-ed as penetrative accelerants。 Its composition was designed by orthogonal test. The percutaneousrelease rate of the ointment was determined in vitro with Holland pig′s skin and cadaver skin。 Theresults showed that accumulative release rate of excellent formulation of cyclosporin A was satis-factory.

关键词

环孢素A / 透皮吸收 / 正交试验

Key words

cyclosporin A / in vitro percutaneous penetration / orthogonal test

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陆晓和;赵仲坤;卓海通;储小曼;贺建国. 环孢素A软膏的处方优选及其体外透皮试验[J]. 中国药学杂志, 1994, 29(08): 473-475
LU Xo-he;ZHO Zong-kun;ZUO Hi-tong;CHU Xo-mn;HE Jn-guo. Ih vitro diffusion in evaluation of various formulations of cyclosporin A[J]. Chinese Pharmaceutical Journal, 1994, 29(08): 473-475

参考文献

1Randak C,Brabletz T,Hergenrother M,et al.Cyclosporin A suppresses the expression of the interleukin 2gene by inhibiting the binding of lympocyte-specific factors to the IL-2enhancer.EMBO ,7,1990,9(8):2529. 2Susan Budavari.The Merck Index,ed 11.USA：Merck and Co，inc,1989:431. 3Kevin D.Mechanisms of cyclosporin A inhibition of anti-gen-presenting activity in uninvoled and lesional psoriatic epidermis.J Invest Dermatol f 1990,9:649. 4Egbaria K.Topical delivery of cyclosporin.J Skin Pharmacol,1990,3(l):21. 5Christopher E M.Cyclosphilin content of normal and pso-riatic epidermis.J Invest Dermatol,1990,94(4):436.

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