Abstract：OBJECTIVE To prepare self-dissolving hyaluronic acid microneedles provide a carrier for transdermal delivery of microneedles and lay a foundation for the preparation of drug-carrying microneedles. METHODS With different molecular weight hyaluronic acid as raw material, according to the solubility of the material, combined with solution fluidity, needle-forming smoothness, microneedle shape state and mechanical strength, the microneedle in good shape, flat and stable array, with good mechanical strength, superior autolysis performance, and low preparation cost with convenience as the index, the process was peatedly screened and optimized. RESULTS Hyaluronic acid with an average molecular weight of 1 000-10 000 was used to prepare a solution with a concentration of 20 mg·mL-1. The pressure was set at -0.07 MPa, the temperature was set at 30 ℃, and the drying time was controlled for about 24 h. The needles were poured to make smooth and smooth hyaluronic acid microneedle with good mechanical properties. CONCLUSION The preparation process is simple, the raw material is easy to get, the product is stable, safe and effective, and it is a good method for the preparation of autolytic hyaluronic acid microneedles. It provides experimental and theoretical basis for the application of microneedle in the new form of medical beauty and skin care, the new way of targeted drug delivery, and the new method of clinical disease drug delivery.
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2020, Vol. 55 
